352 Result(s)

Article

Correction: Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks

Jonathan D. Diedrich, Qian Dong, Daniel C. Ferguson, Brennan P. Bergeron… in Leukemia (2024)

Article

B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4⁺T cell cytotoxicity through ESM1

Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer adaptive immune suppressive response. Uncovering the mechanis...

Jiatao Li, Juan Feng, Ziyong Li, Yuanli Ni, Limei Liu, **a Lei… in npj Precision Oncology (2024)

Article

Activation of lncRNA DANCR by H3K27 acetylation regulates proliferation of colorectal cancer cells

The long noncoding DANCR functions as a tumor oncogene in many cancers, including colorectal cancer (CRC). However, the molecular mechanism of DANCR in CRC has not been explored. This study probed the function...

Yue Han, Ti-Dong Shan, Hai-Tao Huang, Ming-Quan Song, Li Chen, Qian Li in Discover Oncology (2024)

Article

Is there really an accelerated phase of chronic myeloid leukaemia?

Robert Peter Gale, Qian Jiang, Jane F. Apperley, Andreas Hochhaus in Leukemia (2024)

Article

Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3

Targeted therapies have markedly improved the prognosis of lung cancer patients; nevertheless, challenges persist, including limited beneficiary populations and the emergence of drug resistance. This study inv...

Yu Feng, Rulin Qian, Dong Cui, Jiaqiang Luan… in Journal of Cancer Research and Clinical On… (2024)

Article

Point-of-care BCR::ABL1 transcript monitoring using capillary dried blood in chronic myeloid leukemia patients

Olga Sala-Torra, Lan Beppu, Qian Wu, Emily Welch, Erwin Berthier… in Leukemia (2024)

Article

Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study

Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tun...

Yuankai Shi, **aohong Han, Qian Zhao, YuLong Zheng… in Experimental Hematology & Oncology (2024)

Article

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and...

Yun Yang, Qingya Liu, Meng Wang, Lang Li… in Signal Transduction and Targeted Therapy (2024)

Article

Biomarker conversion from primary breast cancer to synchronous axillary lymph node metastasis and neoadjuvant therapy response: a single-center analysis

The biomarker characteristics of breast cancer plays an important role in predicting treatment sensitivity. The aim of the present study was to compare immunohistochemical profiles (ER, PR, HER2, and Ki67) bet...

Mao Ding, Mengyuan Li, Qian Liu… in Journal of Cancer Research and Clinical Oncology (2024)

Article

The biological roles of CD47 in ovarian cancer progression

Ovarian cancer is one of the most lethal malignant tumors, characterized by high incidence and poor prognosis. Patients relapse occurred in 65–80% after initial treatment. To date, no effective treatment has b...

Linan **ng, Zhao Wang, Yue Feng, Haixia Luo… in Cancer Immunology, Immunotherapy (2024)

Article

Oligo-residual disease in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer: incidence, pattern of failure, and clinical value of local consolidative therapy

To investigate the feasibility and potential clinical value of local consolidative therapy (LCT) in PD-1/PD-L1 inhibitor-treated metastatic non-small cell lung cancer (NSCLC).

**meng Zhang, Jie Gao, Shanshan Jiang, Jiuang Mao… in Cancer Immunology, Immunotherapy (2024)

Article

Spatial transcriptomics: a new frontier in cancer research

Tumor research is a fundamental focus of medical science, yet the intrinsic heterogeneity and complexity of tumors present challenges in understanding their biological mechanisms of initiation, progression, an...

Siyuan Huang, Linkun Ouyang, Junjie Tang, Kun Qian… in Clinical Cancer Bulletin (2024)

Article

Two nomograms constructed for predicting the efficacy and prognosis of advanced non‑small cell lung cancer patients treated with anti‑PD‑1 inhibitors based on the absolute counts of lymphocyte subsets

Patients treated with immune checkpoint inhibitors (ICIs) are at risk of considerable adverse events, and the ongoing struggle is to accurately identify the subset of patients who will benefit. Lymphocyte subs...

Aqing Liu, Guan Zhang, Yanjie Yang, Ying **a, Wentao Li… in Cancer Immunology, Immunotherapy (2024)

Article

Is neoadjuvant chemotherapy necessary for T2N0-1M0 hormone receptor-positive/HER2-negative breast cancer patients undergoing breast-conserving surgery?

For HR-positive/HER2-negative patients who can undergo breast-conserving surgery (BCS) but have a tumor size of 2–5 cm or 1–3 lymph node metastases, neoadjuvant chemotherapy (NAC) is still controversial.

Dandan Liu, Lidan Chang, Qian Hao… in Journal of Cancer Research and Clinical On… (2024)

Article

2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide⁺ (NAD⁺)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumu...

Fu Peng, Minru Liao, Wenke **, Wei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Preoperative CT-based radiomic prognostic index to predict the benefit of postoperative radiotherapy in patients with non-small cell lung cancer: a multicenter study

The value of postoperative radiotherapy (PORT) for patients with non-small cell lung cancer (NSCLC) remains controversial. A subset of patients may benefit from PORT. We aimed to identify patients with NSCLC w...

Zeliang Ma, Yu Men, Yunsong Liu, Yongxing Bao, Qian Liu, Xu Yang… in Cancer Imaging (2024)

Article

Hsp90α and cell death in cancers: a review

Heat shock protein 90α (Hsp90α), an important molecular chaperone, plays a crucial role in regulating the activity of various intracellular signaling pathways and maintaining the stability of various signaling...

Bin Liu, Daohai Qian in Discover Oncology (2024)

Article

A pathological joint–liver axis mediated by matrikine-activated CD4⁺ T cells

The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...

Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen… in Signal Transduction and Targeted Therapy (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Case report: Mutation evolution in a patient with TdT positive high grade B cell lymphoma with MYC and BCL2 rearrangements following the treatment of concurrent follicular lymphoma and diffuse large B-cell lymphoma

Concurrent follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)was reported in some studies, while the diagnosis of TdT (terminal deoxynucleotydil transferase) positive high grade B cell lymphoma...

Fen Zhang, Yu Chen, Qian Cui, Yan Ge, Yanhui Liu in Discover Oncology (2024)