166 Result(s)

Article

Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks

Jonathan D. Diedrich, Qian Dong, Daniel C. Ferguson, Brennan P. Bergeron… in Leukemia (2024)

Article

B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4⁺T cell cytotoxicity through ESM1

Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer adaptive immune suppressive response. Uncovering the mechanis...

Jiatao Li, Juan Feng, Ziyong Li, Yuanli Ni, Limei Liu, **a Lei… in npj Precision Oncology (2024)

Article

Activation of lncRNA DANCR by H3K27 acetylation regulates proliferation of colorectal cancer cells

The long noncoding DANCR functions as a tumor oncogene in many cancers, including colorectal cancer (CRC). However, the molecular mechanism of DANCR in CRC has not been explored. This study probed the function...

Yue Han, Ti-Dong Shan, Hai-Tao Huang, Ming-Quan Song, Li Chen, Qian Li in Discover Oncology (2024)

Article

Is there really an accelerated phase of chronic myeloid leukaemia?

Robert Peter Gale, Qian Jiang, Jane F. Apperley, Andreas Hochhaus in Leukemia (2024)

Article

Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3

Targeted therapies have markedly improved the prognosis of lung cancer patients; nevertheless, challenges persist, including limited beneficiary populations and the emergence of drug resistance. This study inv...

Yu Feng, Rulin Qian, Dong Cui, Jiaqiang Luan… in Journal of Cancer Research and Clinical On… (2024)

Article

Point-of-care BCR::ABL1 transcript monitoring using capillary dried blood in chronic myeloid leukemia patients

Olga Sala-Torra, Lan Beppu, Qian Wu, Emily Welch, Erwin Berthier… in Leukemia (2024)

Article

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and...

Yun Yang, Qingya Liu, Meng Wang, Lang Li… in Signal Transduction and Targeted Therapy (2024)

Article

Biomarker conversion from primary breast cancer to synchronous axillary lymph node metastasis and neoadjuvant therapy response: a single-center analysis

The biomarker characteristics of breast cancer plays an important role in predicting treatment sensitivity. The aim of the present study was to compare immunohistochemical profiles (ER, PR, HER2, and Ki67) bet...

Mao Ding, Mengyuan Li, Qian Liu… in Journal of Cancer Research and Clinical Oncology (2024)

Article

Is neoadjuvant chemotherapy necessary for T2N0-1M0 hormone receptor-positive/HER2-negative breast cancer patients undergoing breast-conserving surgery?

For HR-positive/HER2-negative patients who can undergo breast-conserving surgery (BCS) but have a tumor size of 2–5 cm or 1–3 lymph node metastases, neoadjuvant chemotherapy (NAC) is still controversial.

Dandan Liu, Lidan Chang, Qian Hao… in Journal of Cancer Research and Clinical On… (2024)

Article

2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide⁺ (NAD⁺)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumu...

Fu Peng, Minru Liao, Wenke **, Wei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Hsp90α and cell death in cancers: a review

Heat shock protein 90α (Hsp90α), an important molecular chaperone, plays a crucial role in regulating the activity of various intracellular signaling pathways and maintaining the stability of various signaling...

Bin Liu, Daohai Qian in Discover Oncology (2024)

Article

A pathological joint–liver axis mediated by matrikine-activated CD4⁺ T cells

The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...

Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen… in Signal Transduction and Targeted Therapy (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Case report: Mutation evolution in a patient with TdT positive high grade B cell lymphoma with MYC and BCL2 rearrangements following the treatment of concurrent follicular lymphoma and diffuse large B-cell lymphoma

Concurrent follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)was reported in some studies, while the diagnosis of TdT (terminal deoxynucleotydil transferase) positive high grade B cell lymphoma...

Fen Zhang, Yu Chen, Qian Cui, Yan Ge, Yanhui Liu in Discover Oncology (2024)

Article

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YA...

Hui Qian, Chen-Hong Ding, Fang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Artesunate attenuates the tumorigenesis of choroidal melanoma via inhibiting EFNA3 through Stat3/Akt signaling pathway

Choroidal melanoma (CM), a kind of malignant tumor, is the main type of Uveal melanoma and one half of CM patients develop metastases. As a member of Eph/ephrin pathway that plays vital role in tumors, EphrinA...

Ningning Yao, Qingyue Ma, Wendan Yi… in Journal of Cancer Research and Clinical On… (2024)

Article

Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). This phase II study (Cli...

Huaqing Wang, Jifeng Feng, Yanyan Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway

The aim of this study was to investigate the anti-tumor effect of resveratrol (RSV) on glioblastoma (GBM) and its specific mechanism in improving the inflammatory response of the tumor microenvironment. The tu...

Chao Zhang, Qian Peng, Yuhang Tang… in Journal of Cancer Research and Clinical On… (2024)

Article

Artificial intelligence-based assessment of PD-L1 expression in diffuse large B cell lymphoma

Diffuse large B cell lymphoma (DLBCL) is an aggressive blood cancer known for its rapid progression and high incidence. The growing use of immunohistochemistry (IHC) has significantly contributed to the detail...

Fang Yan, Qian Da, Hongmei Yi, Shijie Deng, Lifeng Zhu, Mu Zhou… in npj Precision Oncology (2024)