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Article
Efficacy of the association of lenalidomide to erythropoiesis-stimulating agents in del (5q) MDS patients refractory to single-agent lenalidomide
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Article
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
The phosphatidylinositol 3-kinase (PI3K)/Akt and mammalian target of rapamycin complex 1 (mTORC1) signaling pathways are frequently activated in acute myelogenous leukemia (AML). mTORC1 inhibition with RAD001 ...
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Article
TRAF4 overexpression is a common characteristic of human carcinomas
Tumor necrosis factor receptor (TNFR) associated factor 4 (TRAF4) was initially identified as a gene amplified and overexpressed in breast carcinomas. Our aim was to evaluate whether TRAF4 protein overexpressi...
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Article
Common 4q24 deletion in four cases of hematopoietic malignancy: early stem cell involvement?
We determined bone marrow karyotype at diagnosis in four female acute myeloid leukemia (AML) or myelodysplasia patients, aged between 52 and 56 years. In each case, we observed chromosome rearrangement involvi...
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Article
Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia
Imatinib mesylate (Gleevec®), an inhibitor of the BCR-ABL tyrosine kinase, was introduced recently into the therapy of chronic myeloid leukemia (CML). Several cases of emergence of clonal chromosomal abnormalitie...
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Article
Pure red cell aplasia associated with myelodysplastic syndromes
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Article
Multidrug resistance gene expression in acute myeloid leukemia: Major prognosis significance for in vivo drug resistance to induction treatment
The clinical significance of the multidrug resistance (MDR 1) gene phenotype was investigated in newly diagnosed AML and was compared with other clinical and biological prognostic factors in patients who receive...
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Article
Expression of the transcription factor Evi-1 in human erythroleukemia cell lines and in leukemias
The Evi-1 proto-oncogene is a zinc finger DNA binding protein. Although activation of the Evi-1 gene has been associated with chromosomal rearrangements of the 3q25-q28 region, ectopic expression of Evi-1 coul...
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Article
Male infertility in a case of (Y;6) balanced reciprocal translocation. Mitotic and meiotic study
In a 30-year-old azoospermic male, chromosome analysis revealed an apparently balanced Y-autosome reciprocal translocation, t(Y;6)(Yp6p;Yq6q). Testicular biopsy showed an arrest of spermatogenesis at the First...