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    The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

    Calcineurin inhibitors, such as tacrolimus, are widely used immunosuppressive agents, but they can cause hypertension. In studies of tacrolimus-treated mice, the authors show that hypertension is due to activa...

    Ewout J Hoorn, Stephen B Walsh, James A McCormick, Antje Fürstenberg… in Nature Medicine (2011)