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Article

PGA₁-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes

The cyclopentenone prostaglandin A₁ (PGA₁) is an inducer of cell death in cancer cells. However, the mechanism that initiates this cytotoxic response remains elusive. Here we report that PGA₁ triggers apoptosis b...

B Anta, A Pérez-Rodríguez, J Castro, C A García- Domínguez, S Ibiza… in Cell Death & Disease (2016)