5 Result(s)
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Article
Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems
Sensory neurons in the mouse eye and nose have unusual chromatin organization. Here we report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution, achieved by applying our recently dev...
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Article
Open AccessArsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex
Hepatocellular carcinoma (HCC) has a high mortality rate due to the lack of effective treatments and drugs. Arsenic trioxide (ATO), which has been proved to successfully treat acute promyelocytic leukemia (APL...
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Article
Open AccessOpposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer
Death domain-associated protein (DAXX) is a complex biological multifunctional protein and is involved in the tumorigenesis and progression of multiple cancers. The accumulation of DAXX in the nucleus is a com...
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Article
gem-Difunctionalization of α-diazoarylketones with diaryldiselenides and N-halosuccinimides: facile synthesis of α-halo-α-arylseleno ketones
An efficient synthesis of α-halo-α-arylseleno ketones has been developed via gem-difunctionalization of α-diazoarylketones with diaryldiselenides and N-halosuccinimides. With this multicomponent approach, a seri...
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Article
KOtBu-catalysed α-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes
Herein, we report a KOtBu-catalysed α-homoallylic alkylation of acyclic amides with 1-aryl-1,3-dienes. With this transition metal-free and atom-economic protocol, a series of α-homoallylic alkylated acyclic amide...
