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  1. Article

    Open Access

    Obesity related methylation changes in DNA of peripheral blood leukocytes

    Despite evidence linking obesity to impaired immune function, little is known about the specific mechanisms. Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized tha...

    **aoling Wang, Haidong Zhu, Harold Snieder, Shaoyong Su, David Munn in BMC Medicine (2010)

  2. Article

    Open Access

    Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study

    Metabolomics helps to identify links between environmental exposures and intermediate biomarkers of disturbed pathways. We previously reported variations in phosphatidylcholines in male smokers compared with n...

    Tao Xu, Christina Holzapfel, **ao Dong, Erik Bader, Zhonghao Yu in BMC Medicine (2013)

  3. Article

    Open Access

    Roles of virulence genes (PsaA and CpsA) on the invasion of Streptococcus pneumoniae into blood system

    Streptococcus pneumoniae (SP) is the major cause of childhood mortality worldwide, we need to understand virulence genes of SP so can better target the treatment.

    Da-kang Hu, Dong-guo Wang, Yang Liu, Chi-bo Liu in European Journal of Medical Research (2013)

  4. No Access

    Article

    CEACAM5 is correlated with Angio/Lymphangiogenesis of Prostatic Lesions

    The aim of this study was to examine the expression patterns of CEACAM5 in prostatic non-neoplastic and neoplastic lesions and further investigate its relationship with tumor microvessel density(MVD) and lymph...

    Jie-ke Yan, Yu-zhen Wang, Chuan Tian, Shuang-de Liu in Central European Journal of Medicine (2014)

  5. Article

    Open Access

    Risk factors for post-ERCP pancreatitis: a systematic review of clinical trials with a large sample size in the past 10 years

    Post- endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common and most severe complication associated with diagnostic and therapeutic ERCP. A multivariate analysis of risk f...

    Jian-Jun Chen, **-Mo Wang, **ng-Qiang Liu, Wen Li in European Journal of Medical Research (2014)

  6. Article

    Open Access

    Blocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial

    Chronic hepatitis B (CHB) can progress to cirrhosis, hepatocellular carcinoma (HCC) and ultimately liver-related death. Although oral antiviral therapy for patients with CHB reduces the risk of such complicati...

    Jianhui Qu, Zujiang Yu, Qin Li, Yong** Chen, Dedong **ang, Lin Tan in Trials (2014)

  7. Article

    Open Access

    Hair regrowth in alopecia areata patients following Stem Cell Educator therapy

    Alopecia areata (AA) is one of the most common autoimmune diseases and targets the hair follicles, with high impact on the quality of life and self-esteem of patients due to hair loss. Clinical management and ...

    Yanjia Li, Baoyong Yan, Hepeng Wang, Heng Li, Quanhai Li, Dong Zhao in BMC Medicine (2015)

  8. Article

    Open Access

    Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations

    To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy.

    Longding Liu, Zhaojun Mo, Zhenglun Liang, Ying Zhang, Rongcheng Li in BMC Medicine (2015)

  9. Article

    Open Access

    Danhong injection in the treatment of chronic stable angina: study protocol for a randomized controlled trial

    Chronic stable angina is a leading cause of death worldwide. Danhong injection, a complementary alternative medicine for chronic stable angina, has been demonstrated to be effective in numerous studies and is ...

    Peng Qian Wang, Dan Dan Li, Wei Dong, Jun Liu, Ya Nan Yu, Chun Ti Shen in Trials (2015)

  10. Article

    Open Access

    Effect of ATorvastatin On Chronic subdural Hematoma (ATOCH): a study protocol for a randomized controlled trial

    Chronic subdural hematoma (CSDH) is a common disease that is more prevalent in older people. Surgical intervention is a safe treatment of choice. However, the recurrence rate is relatively high and the outcome...

    Rongcai Jiang, Dong Wang, Wai Sang Poon, Yi Cheng Lu, **n Gang Li, Shi Guang Zhao in Trials (2015)

  11. Article

    Open Access

    Male breast carcinoma: radiotherapy contributed to favorable local control in two cases and related literature review

    Male breast carcinoma (MBC) is rarely encountered in clinical practice. Due to its paucity, our knowledge of MBC only rely on small or single-institutional studies and sporadic cases. The current guidelines fo...

    Min Liu, Qiang Wang, Bin Liu, Ling Gao, Di Wu in European Journal of Medical Research (2015)

  12. Article

    Open Access

    A multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of Tong Luo Hua Shi capsule, a modernized Tibetan medicine, in patients with rheumatoid arthritis

    Tong Luo Hua Shi (TLHS) is a new formulation of the traditional Tibetan medicine Wu-wei-gan-lu that has been used for the treatment of rheumatoid arthritis (RA) for hundreds of years in China. This study aimed...

    Wei Liu, Yuan-Hao Wu, Si-Yuan Hu, Cheng-Liang Zhong, Ming-Li Gao, Dong-Wu Liu in Trials (2016)

  13. Article

    Open Access

    Perioperative and long-term outcomes of liver resection for hepatitis B virus-related hepatocellular carcinoma without versus with hepatic inflow occlusion: study protocol for a prospective randomized controlled trial

    The high prevalence of hepatitis B virus (HBV) imposes a huge burden of hepatocellular carcinoma (HCC) in Asia. Surgical resection remains an important therapeutic strategy for HCC. Hepatic inflow occlusion, k...

    Yinzhe Xu, Jiye Chen, Hongguang Wang, Hui Zheng, Dan Feng, Aiqun Zhang in Trials (2016)

  14. Article

    Open Access

    The Carotid and Middle cerebral artery Occlusion Surgery Study (CMOSS): a study protocol for a randomised controlled trial

    Patients with symptomatic internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion with haemodynamic insufficiency are at high risk for recurrent stroke when treated medically.

    Yan Ma, Yuxiang Gu, **aoguang Tong, Jiyue Wang, Dong Kuai, Donghai Wang, Jun Ren in Trials (2016)

  15. Article

    Open Access

    Rectally administered indomethacin to prevent post-ESWL-pancreatitis (RIPEP): study protocol for a randomized controlled trial

    Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is the first-line therapy for large pancreatic duct stones. Although it is a highly effective and safe procedure for the fragmentation of pancreatic st...

    Yang-Yang Qian, Hui Chen, **n-Ying Tang, ** Jiang, Wei Qian, Wen-Bin Zou, Lei **n in Trials (2017)

  16. Article

    Open Access

    Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: study protocol of a randomized controlled trial

    Postoperative pulmonary complications (PPCs) are major causes of morbidity, mortality, and prolonged hospital stay in patients after surgery. Using effective strategies to prevent its occurrence is essential t...

    Ting Yan, **n-Quan Liang, Tong Wang, Wei-Ou Li, Hui-Juan Li, Sai-Nan Zhu in Trials (2017)

  17. Article

    Open Access

    Chinese herbal medicine Shenzhuo Formula treatment in patients with macroalbuminuria secondary to diabetic kidney disease: study protocol for a randomized controlled trial

    Diabetic kidney disease (DKD) is a serious complication associated with diabetes mellitus and can cause end-stage renal disease (ESRD). Traditional Chinese medicine (TCM) is widely used in China to treat DKD, ...

    Xue-min Zhao, Ying Zhang, **n-hui He, Hong-dong Chen, Zhu-feng Wang, **g Guo in Trials (2018)

  18. Article

    Open Access

    Effect of dual-acupoint and single-acupoint electric stimulation on postoperative outcomes in elderly patients subjected to gastrointestinal surgery: study protocol for a randomized controlled trial

    Transcutaneous electric acupoint stimulation (TEAS) has shown benefits when used peri-operatively. However, the role of numbers of areas with acupoint stimulation is still unclear. Therefore, we report the pro...

    Zhi-hong Lu, Hai-long Dong, Jia-wen Huang-fu, **ao-jian Fan, Wei-xian Zhao in Trials (2018)

  19. Article

    Open Access

    TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over three years in Yunnan, China

    Early diagnosis of congenital syphilis (CS) is difficult. This study aimed to determine the serological response discipline of syphilis passive antibody (SPA) in infants born to mothers with syphilis and provi...

    Hong-Mei Wang, Yu-Ye Li, Li-** He, Ying-Kui Cao in European Journal of Medical Research (2019)

  20. Article

    Open Access

    Analgesia effect of premixed nitrous oxide/oxygen during the rehabilitation after total knee arthroplasty: a study protocol for a randomized controlled trial

    The morbidity of knee arthritis is increasing among aged people and total knee arthroplasty has been its mainstream treatment to date. Postoperative rehabilitation is an important part of the procedure. Howeve...

    Ya-Liang Dai, **ao-Min Chai, Ning Zhu, Kai-Bin Wang, Wen-Qiang Bao, Xue-Sen Zhang in Trials (2019)

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