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  1. Article

    Open Access

    Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis

    Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune ther...

    Olga V. Britanova, Kseniia R. Lupyr, Dmitry B. Staroverov… in Nature Medicine (2023)

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  2. Article

    Open Access

    Exploring the pre-immune landscape of antigen-specific T cells

    Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequen...

    Mikhail V. Pogorelyy, Alla D. Fedorova, James E. McLaren, Kristin Ladell… in Genome Medicine (2018)

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