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A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

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  1. Article

    Open Access

    Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

    Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinosit...

    Marc Lenoir, Cansel Ustunel, Sandya Rajesh, Jaswant Kaur… in Nature Communications (2018)

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  2. Article

    Open Access

    Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication

    Enterovirus 71 (EV71) is a neurotropic enterovirus without antivirals or vaccine, and its host-pathogen interactions remain poorly understood. Here we use a human genome-wide RNAi screen to identify 256 host f...

    Kan **ng Wu, Patchara Phuektes, Pankaj Kumar, Germaine Yen Lin Goh… in Nature Communications (2016)

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