15 Result(s)
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Diana Carvalho
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Open AccessShared decision making, prospektive Lebensqualität und das beste Interesse des Kindes: ethische Herausforderungen im Kontext von Behandlungsentscheidungen bei Frühgeborenen an der Grenze der Lebensfähigkeit
Behandlungsentscheidungen bei Frühgeburten an der Grenze der Lebensfähigkeit stellen eine große Herausforderung dar. In der Neonatologie hat sich das Konzept einer prognostischen Grauzone etabliert, die als ei...
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Fears of compassion scales in psychosis: confirmatory factor analysis and psychometric properties
Previous research has supported the emergence of approaches focused on the cultivation of compassion as a means of decreasing psychopathology and improving well-being. However, some individuals show resistance...
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Open AccessALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2. Despite being an amenab...
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Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
There are two errors and one omission in the original article. Author Gottardo’s correct name is Nicholas G. Gottardo, author Hulleman’s correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements...
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International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma is the most aggressive form of high grade glioma in children with no effective therapies. There have been no improvements in survival in part due poor understanding of underlyi...
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Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells
The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to quantitatively assess the e...
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Performance evaluation of different age groups for gestural interaction: a case study with Microsoft Kinect and Leap Motion
With the thriving of different natural interaction paradigms—such as gesture-based interfaces—it becomes important to understand how these novel interfaces can influence users’ performance when it comes to the...
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Safe use of infliximab for the treatment of severe perianal Crohn’s disease after diagnosis and treatment of lymphoma
Inflammatory bowel disease is associated with an increased likelihood of develo** lymphoma. However, it is still controversial if this risk may be attributed to the disease itself or rather represents an eff...
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Open AccessThe ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion
Astroblastomas are rare brain tumours which predominate in children and young adults, and have a controversial claim as a distinct entity, with no established WHO grade. Reports suggest a better outcome than h...
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Usability evaluation of navigation tasks by people with intellectual disabilities: a Google and SAPO comparative study regarding different interaction modalities
This paper presents a case study regarding the usability evaluation of navigation tasks by people with intellectual disabilities. The aim was to investigate the factors affecting usability, by comparing their ...
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Open AccessOutcomes of endoscopic management of primary and refractory postcholecystectomy biliary leaks in a multicentre review of 178 patients
Biliary leaks have been treated with endoscopic management using different techniques with conflicting results. Furthermore the appropriate rescue therapy for refractory leaks has not been established. We eval...
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Endoscopic Bilio-Duodenal Bypass: Outcomes of Primary and Revision Efficacy of Combined Metallic Stents in Malignant Duodenal and Biliary Obstructions
Self-expandable metal stents (SEMSs) can be used for palliation of combined malignant biliary and duodenal obstructions. However, the results of the concomitant stent placement for the duration of the patients...
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Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Chris Jones, Jacques Grill and colleagues report the identification of recurrent activating mutations in ACVR1 in diffuse intrinsic pontine gliomas.
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Open AccessThe prognostic role of intragenic copy number breakpoints and identification of novel fusion genes in paediatric high grade glioma
Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As function...
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Open AccessThe mirror neuron system in post-stroke rehabilitation
Different treatments for stroke patients have been proposed; among them the mirror therapy and motion imagery lead to functional recovery by providing a cortical reorganization. Up today the basic concepts of ...
