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Open AccessInfluence of corticosteroid treatment on CXCR4 expression in DLBCL
CXCR4-targeted radioligand therapy (RLT) with [177Lu]Lu/[90Y]Y-PentixaTher has recently evolved as a promising therapeutic option for patients with advanced hematological cancers. Given their advanced disease sta...
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Open AccessComparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules
Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between...
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Open AccessInternal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice
Biodistribution studies based on organ harvesting represent the gold standard pre-clinical technique for dose extrapolations. However, sequential imaging is becoming increasingly popular as it allows the extra...
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Open AccessFirst in-human radiation dosimetry of 68Ga-NODAGA-RGDyK
Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RG...