6 Result(s)
within
Article
David Schrama
Biomedicine
-
Article
Open AccessInhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion
The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAFV600 muta...
-
Article
Open AccessIFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression
Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...
-
Article
T cell receptor repertoire usage in cancer as a surrogate marker for immune responses
Characterizing the interaction of cancer cells with the host adaptive immune system is critical for understanding tumor immunology and the modus operandi of immunotherapeutic interventions to treat cancer. As the...
-
Article
Open AccessRelative quantification of TCR Vbeta-chain families by real time PCR for identification of clonal T-cell populations
Quantification of T-cell receptor (TCR) chain families can be utilized for detection of clonal T-cell populations. Besides southern blotting and antibody-based approaches, quantitative real time PCR (qRT PCR) ...
-
Article
Antibody targeted drugs as cancer therapeutics
One way to maximize the effect and minimize the side effects of cancer therapeutics is the targeting of drugs to the tumor by using the specificity of antibodi...
-
Article
Open AccessT-cell clonotypes in cancer
Cells of the immune system spontaneously recognize autologous tumor cells and T cells are believed to be the main effector cells for the immune surveillance of cancer. Recent advances in our understanding of b...
