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Article
Open AccessDeletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37
LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important com...
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Article
Open AccessEffects of midwife-led maternity services on postpartum wellbeing and clinical outcomes in primiparous women under China’s one-child policy
The Midwife-led maternity services have been implemented in China in response to the high rates of primiparous women and Caesarean Sections (CS) which may be related to China’s one-child policy. However, few s...
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Article
LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis
How Wnt signalling including canonical and non-canonical pathways are initiated at the cell surface is not completely understood. Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LR...
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Article
H2O2 Induces Myocardial Hypertrophy in H9c2 Cells: A Potential Role of Ube3a
Myocardial hypertrophy that often leads to eventual heart failure is a leading cause of mortality worldwide. While both apoptosis and cell proliferation have been reported to play an important part in heart fa...