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Article
Open AccessRadiological imaging of teratological fetuses: what can we learn?
To determine the advantages of radiological imaging of a collection of full-term teratological fetuses in order to increase their scientific and educational value.
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Article
In situ detection of antigen-specific T cells in cryo-sections using MHC class I tetramers after dendritic cell vaccination of melanoma patients
Application of tetrameric MHC class I-peptide complexes has significantly improved the monitoring of antigen-specific T cell immune responses in mouse models as well as in clinical studies. Especially MHC clas...
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Article
Micronodular transformation as a novel mechanism of VEGF-A-induced metastasis
How and why tumors metastasize is still a matter of debate. The assumption is that mutations render tumor cells with a metastatic phenotype, enabling entrance in and transport through lymph or blood vessels. D...
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Article
Open AccessAnalysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays
Melanoma is one of the most aggressive types of cancer and resection of the tumour prior to dissemination of tumour cells is still the most effective treatment. Therefore, early diagnosis of melanocytic lesion...
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Article
Open AccessHigh tPA-expression in primary melanoma of the limb correlates with good prognosis
To investigate whether the course of primary melanoma disease correlates with expression of the various components of the proteolytic plasminogen activation (PA) system, immunohistochemical stainings for activ...
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Article
Open AccessMelanoma-inhibiting activity (MIA) mRNA is not exclusively transcribed in melanoma cells: low levels of MIA mRNA are present in various cell types and in peripheral blood
The detection of minimal amounts of melanoma cells by tyrosinase reverse transcription polymerase chain reaction (RT-PCR) is seriously hampered by false negative reports in blood of melanoma patients with diss...
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Article
Open AccessMatrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumour progression and metastasis. In this study, we investigated the in vitro and in vivo expression patterns of MMP-1, MMP...
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Article
Open AccessReproducibility of detection of tyrosinase and MART-1 transcripts in the peripheral blood of melanoma patients: a quality control study using real-time quantitative RT-PCR
In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melano...
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Article
Open AccessComparison of immunohistochemistry with immunoassay (ELISA) for the detection of components of the plasminogen activation system in human tumour tissue
Enzyme-linked immunosorbent assay (ELISA) methods and immunohistochemistry (IHC) are techniques that provide information on protein expression in tissue samples. Both methods have been used to investigate the ...
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Article
Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx
The immunohistochemical expression patterns of cytokeratin polypeptides and vimentin were investigated in normal epithelia and squamous cell carcinomas of the larynx with special emphasis on tumor grading. Dur...
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Article
A lysosomal marker for activated microglial cells involved in Alzheimer classic senile plaques
One of the major histopathological lesions in brains of patients with dementia of the Alzheimer type (DAT) is the senile plaque. Although previous studies have shown that senile plaques are often accompanied b...
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Article
Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid
In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar icht...
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Article
Macrophages in melanocytic naevi
Whereas the inflammatory infiltrates of malignant melanoma have been widely investigated, little is known about the infiltrates accompanying benign melanocytic naevi. Using monoclonal antibodies directed again...
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Article
Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88)
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Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice
In order to study differences in antigen expression related to the different stages of the process of metastasis of human melanoma cell lines, we determined the expression pattern of a series of well-character...
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Article
Ichthyosis bullosa of Siemens: Further delineation of the phenotype
We report a third family affected with ichthyosis bullosa of Siemens, and we further delineate the clinical spectrum of this mild type of epidermolytic hyperkeratosis. Erythroderma had never been present in an...
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Article
Monoclonal antibodies in detection of choroidal melanoma
Three monoclonal antibodies (MoAbs) prepared against cutaneous melanomas were tested against one group of 12 choroidal melanomas with indirect immunofluorescence in frozen sections. A fourth MoAb was tested in...
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Article
Distribution of cytokeratin polypeptides in epithelia of the adult human urinary tract
Cytokeratin expression was studied in the epitheha lining the normal human urine conducting system using immunohistochemistry on frozen sections employing a panel of 14 monoclonal antibodies. Eleven of these a...
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Article
Magnetic resonance imaging in the diagnosis and staging of renal masses: a critical appraisal and comparison with computed tomography
The purpose of this prospective study was to compare the accuracy of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis and staging of renal masses. MRI was performed with an 0.5 T ...
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Late abstracts 186–187
