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Article
Increased interictal spike activity associated with transient slow wave trains during non-rapid eye movement sleep
Non-rapid eye movement (NREM) sleep is characterized by recurring transient events (Cyclic Alternating Patterns, CAP), some of which consist of increased slow wave activity (A1 subtype). Such transient slow-wa...
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Article
Dabrafenib Therapy in 30 Patients with Melanoma Metastatic to the Brain: a Single-centre Controlled Retrospective Study in Hungary
Dabrafenib is a potent BRAF inhibitor, which showed intracranial tumor activity. The purpose of our retrospective analysis was to evaluate the efficacy of dabrafenib for patients with melanoma brain metastasis...
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Increased cortical involvement and synchronization during CAP A1 slow waves
Slow waves recorded with EEG in NREM sleep are indicative of the strength and spatial extent of synchronized firing in neuronal assemblies of the cerebral cortex. Slow waves often appear in the A1 part of the ...
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Open AccessThe role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy
When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide addi...
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Open AccessBursting of excitatory cells is linked to interictal epileptic discharge generation in humans
Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interi...
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Open AccessThe sleep EEG envelope is a novel, neuronal firing-based human biomarker
Sleep EEG reflects voltage differences relative to a reference, while its spectrum reflects its composition of various frequencies. In contrast, the envelope of the sleep EEG reflects the instantaneous amplitu...
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Article
Open AccessIntracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans
Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgic...
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Article
Open AccessDifferential cortical layer engagement during seizure initiation and spread in humans
Despite decades of research, we still do not understand how spontaneous human seizures start and spread – especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-elect...