15 Result(s)
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Cindy H. Chau
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Open AccessAuthor Correction: Liquid biopsy epigenomic profiling for cancer subty**
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Bridging Health Disparities: a Genomics and Transcriptomics Analysis by Race in Prostate Cancer
As the era of cancer genomics expands, disproportionate rates of prostate cancer incidence and mortality by race have demonstrated increasing relevance in clinical settings. While Black men are most particular...
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Open AccessLiquid biopsy epigenomic profiling for cancer subty**
Although circulating tumor DNA (ctDNA) assays are increasingly used to inform clinical decisions in cancer care, they have limited ability to identify the transcriptional programs that govern cancer phenotypes...
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Open AccessTargeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex
Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergisticall...
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Open AccessAbiraterone induces SLCO1B3 expression in prostate cancer via microRNA-579-3p
Understanding mechanisms of resistance to abiraterone, one of the primary drugs approved for the treatment of castration resistant prostate cancer, remains a priority. The organic anion polypeptide 1B3 (OATP1B...
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Resistance to second-generation androgen receptor antagonists in prostate cancer
The introduction of second-generation androgen receptor antagonists (SG-ARAs) has greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious alternatives to chemotherapy....
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Open AccessPilot study of gadoxetate disodium-enhanced mri for localized and metastatic prostate cancers
OATP1B3 is expressed de novo in primary prostate cancer tissue and to a greater degree in prostate cancer metastases. Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate w...
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Open AccessCereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide
Carfilzomib-lenalidomide-dexamethasone (KRd) therapy has yielded promising results in patients with newly diagnosed multiple myeloma (NDMM). Cereblon (CRBN) is the direct molecular target of lenalidomide and g...
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Revisiting 5α-reductase inhibitors and the risk of prostate cancer
The role of 5α-reductase inhibitors (5-ARI) in prostate cancer chemoprevention remains a controversy, as cancer prevention trials with 5-ARIs have shown a decreased incidence of low-grade prostate cancer but a...
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Open AccessShared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model
Angiogenesis, the formation of new blood vessels, is essential for tumor growth, stabilization and progression. Angiogenesis inhibitors are now widely used in the clinic; however, there are relatively few publ...
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A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms
To determine the maximum tolerated dose (MTD) of perifosine (NSC 639966), an alkylphospholipid modulator of signal transduction, using different oral loading and maintenance regimens in an effort to avoid gast...
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Open AccessEpidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer
The downstream targets of hypoxia inducible factor-1 alpha (HIF-1α) play an important role in tumor progression and angiogenesis. Therefore, inhibition of HIF-mediated transcription has potential in the treatm...
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Open AccessChallenges to improved therapeutics for metastatic castrate resistant prostate cancer: from recent successes and failures
Men with metastatic castration-resistant prostate cancer (mCRPC) carry poor prognosis despite the use of docetaxel-based regimens which has modest survival benefit shown by randomized clinical trials. Signific...
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Mechanisms of Disease: polymorphisms of androgen regulatory genes in the development of prostate cancer
Despite the numerous androgen receptor gene polymorphisms that have been identified, no specific polymorphism has been linked with an increased risk of prostate cancer. Arun Singh and coauthors discuss these v...
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Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
Etk/Bmx, a member of the Tec family of non-receptor tyrosine kinase, is characterized by an N-terminal PH domain and has recently been shown to be involved in the regulation of various cellular processes, incl...
