272 Result(s)
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Article
Chunfang **
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Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates
Severe acute respiratory syndrome (SARS) caused by SARS-associated coronavirus (SARS-CoV) is a fatal disease. Prevention of future outbreaks is essential and requires understanding pathogenesis and evolution o...
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Amino acids 1 to 422 of the spike protein of SARS associated coronavirus are required for induction of cyclooxygenase-2
The causative agent of severe acute respiratory syndrome (SARS) has been identified as SARS-associated coronavirus (SARS-CoV). To evaluate the molecular mechanisms involved in the viral infection, in this stud...
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Open AccessMolecular epidemiology of measles viruses in China, 1995–2003
This report describes the genetic characterization of 297 wild-type measles viruses that were isolated in 24 provinces of China between 1995 and 2003. Phylogenetic analysis of the N gene sequences showed that ...
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Open AccessAssociations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study
Preeclampsia involves endothelial dysfunction, platelet dysfunction/activation and sympathetic over-activity similar to cardiovascular disorders (CVD). Depression, an independent risk factor for progression of...
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Open AccessFixed Point Theorems for Times Reasonable Expansive Map**
Based on previous notions of expansive map**, times reasonable expansive map** is defined. The existence of fixed point for ...
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Open AccessMultichromosomal median and halving problems under different genomic distances
Genome median and genome halving are combinatorial optimization problems that aim at reconstructing ancestral genomes as well as the evolutionary events leading from the ancestor to extant species. Exploring c...
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Open AccessEarly pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study
Preterm delivery (PTD) is a significant public health problem associated with greater risk of mortality and morbidity in infants and mothers. Pathophysiologic processes that may lead to PTD start early in preg...
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Open AccessEpstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation
The Epstein-Barr virus (EBV)-encoded EBNA1 protein is expressed in all EBV-associated tumours, including undifferentiated nasopharyngeal carcinoma (NPC), where it is indispensable for viral replication, genome...
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Open AccessGlucose intolerance and gestational diabetes risk in relation to sleep duration and snoring during pregnancy: a pilot study
Insufficient sleep and poor sleep quality, considered endemic in modern society, are associated with obesity, impaired glucose tolerance and diabetes. Little, however, is known about the consequences of insuff...
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Open AccessThe collapse of gene complement following whole genome duplication
Genome amplification through duplication or proliferation of transposable elements has its counterpart in genome reduction, by elimination of DNA or by gene inactivation. Whether loss is primarily due to excis...
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Open AccessScaffold filling, contig fusion and comparative gene order inference
There has been a trend in increasing the phylogenetic scope of genome sequencing without finishing the sequence of the genome. Increasing numbers of genomes are being published in scaffold or contig form. Rear...
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Open AccessEpstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors
Epstein-Barr Virus (EBV)-encoded RNAs (EBERs) are non-polyadenylated RNA molecules transcribed from the EBV genome by RNA polymerase III (pol III). EBERs are the most abundant viral latent gene products, altho...
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Open AccessPopulation genetics of foxtail millet and its wild ancestor
Foxtail millet (Setaria italica (L.) P. Beauv.), one of the most ancient domesticated crops, is becoming a model system for studying biofuel crops and comparative genomics in the grasses. However, knowledge on th...
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Open AccessEfficacy of c-Met inhibitor for advanced prostate cancer
Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuatio...
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Open AccessSleep duration, vital exhaustion and perceived stress among pregnant migraineurs and non-migraineurs
Migraine has been associated with sleep disorders in men and non-pregnant women, but little is known about sleep complaints among pregnant migraineurs.
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Open AccessOn the PATHGROUPS approach to rapid small phylogeny
We present a data structure enabling rapid heuristic solution to the ancestral genome reconstruction problem for given phylogenies under genomic rearrangement metrics. The efficiency of the greedy algorithm is...
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Open AccessAssociation between metabolic abnormalities and HBV related hepatocelluar carcinoma in Chinese: A cross-sectional study
Previous studies suggested that the abnormality of metabolism is a newly identified risk factor in HBV-related hepatocellular carcinoma (HCC). The association between metabolic factors and hepatocellular carci...
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Open AccessFacile synthesis of concentrated gold nanoparticles with low size-distribution in water: temperature and pH controls
The citrate reduction method for the synthesis of gold nanoparticles (GNPs) has known advantages but usually provides the products with low nanoparticle concentration and limits its application. Herein, we rep...
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Open AccessMonotone and convex positive solutions for fourth-order multi-point boundary value problems
The existence results of multiple monotone and convex positive solutions for some fourth-order multi-point boundary value problems are established. The nonlinearities in the problems studied depend on all orde...
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Open AccessComparative transcriptome sequencing of germline and somatic tissues of the Ascaris suum gonad
Ascaris suum (large roundworm of pigs) is a parasitic nematode that causes substantial losses to the meat industry. This nematode is suitable for biochemical studies because, unlike C. elegans, homogeneous tissue...
