40 Result(s)
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Article
Photo-induced cold vapor generation with low molecular weight alcohol, aldehyde, or carboxylic acid for atomic fluorescence spectrometric determination of mercury
With UV irradiation, Hg2+ in aqueous solution can be converted into Hg0 cold vapor by low molecular weight alcohols, aldehydes, or carboxylic acids, e.g., methanol, formaldehyde, acetaldehyde, glycol, 1,2-propane...
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The therapeutic function of the chemokine RANTES on the H22 hepatoma ascites model
This study aimed at analyzing the therapeutic function of the chemokine RANTES on the H22 hepatoma ascites model and preliminarily explore the mechanism of RANTES in malignant ascites to provide an important r...
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Article
Identification of New Dominant-Negative Mutants of Anthrax Protective Antigen Using Directed Evolution
The anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema toxin (EF). The PA moiety carries EF and LF into the cytosol of mammalian cells via a mechanism that depe...
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Article
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
A small molecule that disrupts interaction between Nur77 and LKB1 leads to LKB1 exit from the nucleus to activate cytoplasmic AMPK and, ultimately, reduces blood glucose and insulin in diabetic mice. ...
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Article
SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1
Sirtuin 1 (SIRT1), a NAD+-dependent class III histone deacetylase, participates in regulating cellular apoptosis, senescence and metabolism by deacetylating histones and multiple transcription factors. In this st...
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Article
Determination of ecgonine and seven other cocaine metabolites in human urine and whole blood by ultra-high-pressure liquid chromatography–quadrupole time-of-flight mass spectrometry
Ecgonine is suggested to be a promising marker of cocaine (COC) ingestion. A combined mass spectrometry (MS) and tandem MS (MS/MS) method was developed to simultaneously determine ecgonine and seven other meta...
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Article
High secretory production of an alkaliphilic actinomycete xylanase and functional roles of some important residues
Using native signal peptide, an alkaliphilic actinomycete xylanase XynK was overexpressed in Escherichia coli and secreted into the culture medium completely. At its optimum catalytic temperature of 55 °C, the c...
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Article
Open AccessPolymerase chain reaction–based assays for the diagnosis of human brucellosis
Polymerase chain reaction (PCR) is an in vitro technique for the nucleic acid amplification, which is commonly used to diagnose infectious diseases. The use of PCR for pathogens detection, genoty** and quant...
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Article
Genomic reconstruction to improve bioethanol and ergosterol production of industrial yeast Saccharomyces cerevisiae
Baker’s yeast (Saccharomyces cerevisiae) is the common yeast used in the fields of bread making, brewing, and bioethanol production. Growth rate, stress tolerance, ethanol titer, and byproducts yields are some of...
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Approaches for the generation of active papain-like cysteine proteases from inclusion bodies of Escherichia coli
Papain-like cysteine proteases are widely expressed, fulfill specific functions in extracellular matrix turnover, antigen presentation and processing events, and may represent viable drug targets for major dis...
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Article
Design, synthesis and antiproliferative evaluation of some B-homo steroidal lactams
A series of 3-substituted-6-aza-B-homo-5-α-stigmastan-7-one and 3-substituted-6-aza-B-homo-5-α-sitostan-7-one derivatives were designed and synthesized by the oxidation, reduction, oximation, Beckman rearrang...
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Article
Comparison of microarray and RNA-Seq analysis of mRNA expression in dermal mesenchymal stem cells
We characterized mRNA expression profiles in normal and psoriatic human dermal mesenchymal stem cells (DMSCs) to provide a reference for future investigation of differential gene expression in DMSCs.
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Article
Blood Cadmium Level Associates with Lower Testosterone and Sex Hormone-Binding Globulin in Chinese men: from SPECT-China Study, 2014
Cadmium is a widespread environmental pollutant. We aimed to determine whether blood cadmium level (BCL) associates with reproductive hormones in a cross-sectional study. Our data were from SPECT-China. We sel...
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Article
Dynamic transcriptome analysis reveals AP2/ERF transcription factors responsible for cold stress in rapeseed (Brassica napus L.)
The APETALA2/ethylene response factor (AP2/ERF) transcription factor (TF) superfamily plays an important regulatory role in signal transduction of the plant responses to various stresses including low temperat...
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Article
Expression and functional analysis of two NhaD type antiporters from the halotolerant and alkaliphilic Halomonas sp. Y2
Na+/H+ antiporters play important roles in ion and pH homeostasis. In this study, two NhaD homologues that effectively catalyze Na+/H+ antiporter were identified from Halomonas sp. Y2, a halotolerant and alkaliph...
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Article
Long-range temporal correlations of broadband EEG oscillations for depressed subjects following different hemispheric cerebral infarction
Abnormal long-range temporal correlation (LRTC) in EEG oscillation has been observed in several brain pathologies and mental disorders. This study examined the relationship between the LRTC of broadband EEG os...
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Article
Epidemiological Trends in Gastrointestinal Cancers in China: An Ecological Study
In recent decades, the patterns and trends of gastrointestinal (GI) cancer epidemics in Chinese population have been changing.
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Article
Open AccessLINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1/STAT3 pathway
Lung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators of diverse biological proces...
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Article
Isoelectric focusing on microfluidic paper-based chips
Isoelectric focusing (IEF), a powerful technique for protein separation and enrichment, was successfully integrated into microfluidic paper-based analytical devices (μPADs) in this work. The μPADs for isoelect...
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Article
Approximate analytic solutions for a chemical tubular reactor model using the Adomian decomposition method
The purpose of this paper is to apply the Adomian decomposition method to acquire the approximate analytical solutions for a chemical tubular reactor model composed of a system of strongly nonlinear second-ord...
