11 Result(s)
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Chuanqi Zhao
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Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands
Despite the demonstrated importance of DNA G-quadruplexes (G4s) in health and disease, technologies to readily manipulate specific G4 folding for functional analysis and therapeutic purposes are lacking. Here ...
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Open AccessA bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses
Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we construct a synergistic nanoplatf...
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Spray cooling heat transfer enhancement by ethanol additive: Effect of Sauter mean diameter and fluid volumetric flux
Due to the excellent heat transfer performance, spray cooling is widely used for heat removal of high-heat-flux electronic devices. In this study, the influence of spray characteristics on spray cooling heat t...
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Hydrogen-bonded organic framework-based bioorthogonal catalysis prevents drug metabolic inactivation
Bioorthogonal chemistry provides a new avenue for disease treatment by generating therapeutic agents in situ. However, two crucial issues have to be considered for future practical applications. One is the pre...
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Correction to: Effective degradation of tetracycline via recyclable free-standing three-dimensional copper-based graphene as a persulfate catalyst
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Effective degradation of tetracycline via recyclable free-standing three-dimensional copper-based graphene as a persulfate catalyst
Water pollution by antibiotics is a serious and growing problem. Given this challenge, a free-standing three-dimensional (3D) reduced graphene oxide foam supported copper oxide nanoparticles (3D-rGO-CuxO) was syn...
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Open AccessRNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models
The ongoing COVID-19 pandemic has continued to affect millions of lives worldwide, leading to the urgent need for novel therapeutic strategies. G-quadruplexes (G4s) have been demonstrated to regulate life cycl...
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Influence of graphene oxide nanosheets on the cotransport of cu-tetracycline multi-pollutants in saturated porous media
Antibiotic-heavy metal multi-pollutants are produced by intensive livestock farming and become an increasingly prominent problem. In this study, the transport behavior of tetracycline (TC) and its chelate with...
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Adsorption performance and mechanism of magnetic reduced graphene oxide in glyphosate contaminated water
In this study, the magnetic reduced graphene oxide (RGO/Fe3O4), with easy separation and high adsorption performance, was prepared and used to treat glyphosate (GLY) contaminated water. GLY adsorption performance...
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Potential coupling effects of ammonia-oxidizing and anaerobic ammonium-oxidizing bacteria on completely autotrophic nitrogen removal over nitrite biofilm formation induced by the second messenger cyclic diguanylate
The objective of this study was to investigate the influence of extracellular polymeric substance (EPS) on the coupling effects between ammonia-oxidizing bacteria (AOB) and anaerobic ammonium-oxidizing (anammo...
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Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres
Both human telomeric G-rich and C-rich DNA have been considered as specific drug targets for cancer therapy. However, due to i-motif structure instability and lack of specific binding agents, it remains unclea...
