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  1. No Access

    Article

    New finding of nalbuphine metabolites in men: NMR spectroscopy and UPLC–MS/MS spectrometry assays in a pilot human study

    A safe and efficient semi-synthetic narcotic nalbuphine (NAL) which was broadly applied in analgesic therapy has long been considered to eliminate from human body via phase II conjugation. However, up to the p...

    Hong-Jaan Wang, Cheng-Huei Hsiong, Li-Heng Pao, Wen-Liang Chang… in Metabolomics (2014)

  2. No Access

    Article

    Commonly Used Excipients Modulate UDP-Glucuronosyltransferase 2B7 Activity to Improve Nalbuphine Oral Bioavailability in Humans

    Nalbuphine (NAL) is a potent opioid analgesic, but can only be administered by injection. The major aim of this study was to develop an oral NAL formulation employing known excipients as UDP-glucuronosyltransf...

    Hong-Jaan Wang, Cheng-Huei Hsiong, Shung-Tai Ho, Min-Jen Lin… in Pharmaceutical Research (2014)

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    Article

    Genetic Polymorphisms of Metabolic Enzymes and the Pharmacokinetics of Indapamide in Taiwanese Subjects

    To understand the genetic makeup and impact on pharmacokinetics (PK) in the Taiwanese population, we analyzed the pharmacogenetic (PG) profile and demonstrated its effects on enzyme metabolism using indapamide...

    Teng-Hsu Wang, Cheng-Huei Hsiong, Hsin-Tien Ho, Tung-Yuan Shih… in The AAPS Journal (2014)

  4. No Access

    Article

    Dietary Flavonoids Modulate CYP2C to Improve Drug Oral Bioavailability and Their Qualitative/Quantitative Structure–Activity Relationship

    This study aims to improve the drug oral bioavailability by co-administration with flavonoid inhibitors of the CYP2C isozyme and to establish qualitative and quantitative (QSAR) structure–activity relationship...

    Hong-Jaan Wang, Li-Heng Pao, Cheng-Huei Hsiong, Tung-Yuan Shih… in The AAPS Journal (2014)

  5. No Access

    Article

    Simultaneous Determination of Buprenorphine, Norbuprenorphine and Naloxone in Human Plasma by LC-MS-MS

    A novel sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method simultaneously determined buprenorphine (BUP) and its active metabolite, norbuprenorphine (NBUP), and a coformul...

    Ting-Yi Chiang, Li-Heng Pao, Cheng-Huei Hsiong, Pei-Wei Huang… in Chromatographia (2011)