8 Result(s)
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Article
Open AccessRational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis
Oritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and only antibiotic with a single-dose therapeutic regimen to treat ABSSSI. ...
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Article
Open AccessEngineering Saccharomyces cerevisiae for improved biofilm formation and ethanol production in continuous fermentation
Biofilm-immobilized continuous fermentation has the potential to enhance cellular environmental tolerance, maintain cell activity and improve production efficiency.
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Article
Open AccessEnhanced accumulation of oil through co-expression of fatty acid and ABC transporters in Chlamydomonas under standard growth conditions
Chloroplast and endoplasmic reticulum (ER)-localized fatty acid (FA) transporters have been reported to play important roles in oil (mainly triacylglycerols, TAG) biosynthesis. However, whether these FA transp...
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Article
Open AccessRedirection of the central metabolism of Klebsiella pneumoniae towards dihydroxyacetone production
Klebsiella pneumoniae is a bacterium that can be used as producer for numerous chemicals. Glycerol can be catabolised by K. pneumoniae and dihydroxyacetone is an intermediate of this catabolism pathway. Here dihy...
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Article
Open AccessExpression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression
Most patients with acute myeloid leukemia (AML) remain uncurable and require novel therapeutic methods. Gain-of-function FMS-like tyrosine kinase 3 (FLT3) mutations are present in 30–40% of AML patients and se...
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Article
Open AccessHydrodynamic performance of floating photobioreactors driven by wave energy
Unlike conventional cultivation systems, liquid mixing in floating photobioreactors (PBRs) is solely induced by their hydrodynamic movement in response to waves, and this movement is affected by the wave condi...
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Open AccessA recycling culture of Neochloris oleoabundans in a bicarbonate-based integrated carbon capture and algae production system with harvesting by auto-flocculation
A bicarbonate-based integrated carbon capture and algae production system (BICCAPS) uses carbonate to capture CO2 and produce bicarbonate for alkalihalophilic microalgal cultivation. In this process, carbonate is...
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Article
Open AccessA novel strategy to improve protein secretion via overexpression of the SppA signal peptide peptidase in Bacillus licheniformis
Signal peptide peptidases play an important role in the removal of remnant signal peptides in the cell membrane, a critical step for extracellular protein production. Although these proteins are likely a centr...
