59 Result(s)

Article

Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer

Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used meta...

Chengpei Zhu, Yunchao Wang, Ruijuan Zhu, Shanshan Wang, **gnan Xue… in Biomarker Research (2024)

Article

Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...

Guo-Tian Ruan, Li Deng, Hai-Lun **e, **-Yu Shi, **ao-Yue Liu… in Cancer & Metabolism (2024)

Article

Personalized tumor combination therapy optimization using the single-cell transcriptome

The precise characterization of individual tumors and immune microenvironments using transcriptome sequencing has provided a great opportunity for successful personalized cancer treatment. However, the cancer ...

Chen Tang, Shaliu Fu, Xuan **, Wannian Li, Feiyang **ng, Bin Duan… in Genome Medicine (2023)

Article

Disulfidptosis-associated long non-coding RNA signature predicts the prognosis, tumor microenvironment, and immunotherapy and chemotherapy options in colon adenocarcinoma

Disulfidptosis is independent of apoptosis, ferroptosis, and cuproptosis and is associated with cancer progression, treatment response, and prognosis. However, the predictive potential of disulfidptosis-associ...

Weijie Xue, Kang Qiu, Bingzi Dong, Dong Guo, Junhua Fu… in Cancer Cell International (2023)

Article

CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90β complex

The identification of key regulatory factors that control osteoclastogenesis is important. Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional entities. However, the complexit...

Kun Chen, ** Chen, Chuandong Lang, **ngshi Yuan… in Experimental & Molecular Medicine (2023)

Article

Noninvasive and affordable type 2 diabetes screening by deep learning-based risk assessment and detection using ophthalmic images inspired by traditional Chinese medicine

The global prevalence of diabetes is steadily increasing, with a high percentage of patients unaware of their disease status. Screening for diabetes is of great significance in preventive medicine and may bene...

Zhi Zhang, Han Wang, Lei Chen, Chensi Cao, Tengwen Liu, Ruifang Ren, Ruixing Zhou… in Med-X (2023)

Article

Genetic basis of STEM occupational choice and regional economic performance: a UK biobank genome-wide association study

Science, technology, engineering, and mathematics (STEM) professionals are regarded as the highly skilled labor force that fosters economic productivity, enterprise innovation, and international competitivenes...

Chen Zhu, Qiran Zhao, Jianbo He, Petri Böckerman, Siyang Luo, Qihui Chen in Human Genomics (2023)

Article

Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human health and economy globally. Curati...

Bo Li, Hui Chen, Shaohua Yang, Feng Chen, Liangliang Xu, Yan Li… in Molecular Cancer (2023)

Article

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in...

Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand… in Nature Medicine (2023)

Article

Novel DNA methylation biomarkers in stool and blood for early detection of colorectal cancer and precancerous lesions

Early detection and prevention of precancerous lesions can significantly reduce the morbidity and mortality of colorectal cancer (CRC). Here, we developed new candidate CpG site biomarkers for CRC and evaluate...

Yuguang Shen, Dongyang Wang, Tianli Yuan, Hongsheng Fang, Chen Zhu… in Clinical Epigenetics (2023)

Article

SRC kinase-mediated signaling pathways and targeted therapies in breast cancer

Breast cancer (BC) has been ranked the most common malignant tumor throughout the world and is also a leading cause of cancer-related deaths among women. SRC family kinases (SFKs) belong to the non-receptor ty...

Juan Luo, Hailin Zou, Yibo Guo, Tongyu Tong, Li** Ye… in Breast Cancer Research (2022)

Article

Heritability of tomato rhizobacteria resistant to Ralstonia solanacearum

Ralstonia solanacearum (Rs) is a soilborne phytopathogen that causes bacterial wilt and substantial yield losses in many plants, such as tomatoes. A resistant tomato cultivar can recruit a beneficial microbiome f...

Jiakang Yin, Ziliang Zhang, Chengcheng Zhu, Taotao Wang, Ruihong Wang… in Microbiome (2022)

Article

Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling

The role of JAM3 in different tumors is controversial. The epigenetic regulation and the mechanism of JAM3 remain to be elucidated in human esophageal cancer (EC).

Weili Yang, Chao Guo, James G. Herman, Cheng Zhu, Honghui Lv… in Clinical Epigenetics (2022)

Article

The role of ferroptosis in esophageal cancer

Esophageal cancer is one of the most common cancers with high mortality rate around the world. Although the treatment strategy of this disease has made great progress, the prognosis of advanced patients is not...

Zimin Wang, Sikai Wu, Chengchu Zhu, Jianfei Shen in Cancer Cell International (2022)

Article

Toll-like receptors and their role in neuropathic pain and migraine

Migraine is a complex neurological disease of unknown etiology involving both genetic and environmental factors. It has previously been reported that persistent pain may be mediated by the immune and inflammat...

Xuejiao Liu, Wen** Yang, Chenlu Zhu, Songtang Sun, Shouyi Wu… in Molecular Brain (2022)

Article

Low-Dose Ziprasidone in Combination with Sertraline for First-Episode Drug-Naïve Patients with Schizophrenia: a Randomized Controlled Trial

Many patients with schizophrenia (SCZ) discontinue antipsychotics, frequently due to dose-related multiple and severe adverse effects. We hypothesized that a low-dose ziprasidone plus sertraline would reduce s...

Cheng Zhu, **aoni Guan, Yuechan Wang, Jiahong Liu, Thomas R. Kosten… in Neurotherapeutics (2022)

Article

Autoimmunity is a hallmark of post-COVID syndrome

Autoimmunity has emerged as a characteristic of the post-COVID syndrome (PCS), which may be related to sex. In order to further investigate the relationship between SARS-CoV-2 and autoimmunity in PCS, a clinic...

Manuel Rojas, Yhojan Rodríguez, Yeny Acosta-Ampudia… in Journal of Translational Medicine (2022)

Article

miR-30a targets STOX2 to increase cell proliferation and metastasis in hydatidiform moles via ERK, AKT, and P38 signaling pathways

A hydatidiform mole is a condition caused by abnormal proliferation of trophoblastic cells. MicroRNA miR-30a acts as a tumor suppressor gene in most tumors and participates in the development of various cancer...

Zhenzhen Guo, Chenyu Zhu, Youhui Wang, Zhen Li, Lu Wang… in Cancer Cell International (2022)

Article

RETRACTED ARTICLE: MiR-151-3p transferred by cancer-associated fibroblast-derived extracellular vesicles promotes osteosarcoma progression through the CHL1/integrin 1β/TGF-β axis

Peng Wang, Changchao Wang, Leyin Zhu, ** Li, **aobo Tang… in Cancer Gene Therapy (2021)

Article

Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care

Human papillomavirus (HPV) infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human cancers. Up to 38%–80% of head and neck squamous cell c...

Haoru Dong, **nhua Shu, Qiang Xu, Chen Zhu, Andreas M. Kaufmann… in Virologica Sinica (2021)