12 Result(s)
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Article
Changsong Yang
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Open AccessA phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion
Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs) dock and fuse with the plasma membrane. However, MVEs are also known to fuse with lysosomes for degradation. How MVEs are ...
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Open AccessFeedback between mechanosensitive signaling and active forces governs endothelial junction integrity
The formation and recovery of gaps in the vascular endothelium governs a wide range of physiological and pathological phenomena, from angiogenesis to tumor cell extravasation. However, the interplay between th...
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Open AccessActin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges
Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in mechanically challenging conditions. The roles of actin in CME are poorly understood due to inadequate knowledge of actin ...
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Open AccessHRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors
The lack of tumor infiltration by CD8+ T cells is associated with poor patient response to anti-PD-1 therapy. Understanding how tumor infiltration is regulated is key to improving treatment efficacy. Here, we rep...
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Efficient data transfer supporting provable data deletion for secure cloud storage
With the widespread popularity of cloud storage, a growing quantity of tenants prefer to upload their massive data to remote cloud data center for saving local cost. Due to the great market prospect, a large q...
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Open AccessT-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relative...
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Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein
The dynamin GTPase is known to bundle actin filaments, but the underlying molecular mechanism and physiological relevance remain unclear. Our genetic analyses revealed a function of dynamin in propelling invas...
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Ultrastructure and dynamics of the actin−myosin II cytoskeleton during mitochondrial fission
Mitochondrial fission involves the preconstriction of an organelle followed by scission by dynamin-related protein Drp1. Preconstriction is facilitated by actin and non-muscle myosin II through a mechanism tha...
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Open AccessGraph database-based network security situation awareness data storage method
With the rapid development of the Internet, network security situation awareness has attracted tremendous attention. In large-scale complex networks, network security situation awareness data presents the char...
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Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors
IRSp53 is a BAR-domain protein under the control of Rho family GTPases and has crucial roles in processes such as cell motility and tumor invasiveness. In a new study, IRSp53 is shown to be autoinhibited and i...
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CARMIL leading edge localization depends on a non-canonical PH domain and dimerization
CARMIL is an approximately 1,370-amino-acid cytoskeletal scaffold that has crucial roles in cell motility and tissue development through interactions with cytoskeletal effectors and regulation of cap** prote...
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Visualizing branched actin filaments in lamellipodia by electron tomography
