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    Article

    Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1

    The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces bot...

    Luara Isabela dos Santos, Bruno Galvão-Filho… in Cancer Immunology, Immunotherapy (2015)

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    Article

    γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis

    Activated Vγ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum–infected patients. Although previous studies suggested that γδ2 T cells help control erythro...

    Caroline Junqueira, Rafael B. Polidoro, Guilherme Castro… in Nature Immunology (2021)