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  1. No Access

    Article

    Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

    Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies show reversible downregulation of brain cannabinoid CB1 (cannabinoid receptor type 1) receptors after chronic exposure to can...

    J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse… in Molecular Psychiatry (2012)

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    Article

    Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography

    Brain cannabinoid CB1 receptors contribute to alcohol-related behaviors in experimental animals, but their potential role in humans with alcohol dependence is poorly understood. We measured CB1 receptors in alcoh...

    J Hirvonen, P Zanotti-Fregonara, J C Umhau, D T George… in Molecular Psychiatry (2013)

  3. No Access

    Article

    Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study

    A previous genetic study has suggested that schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) share common disease-a...

    C-M Cheng, W-H Chang, M-H Chen, C-F Tsai, T-P Su, C-T Li, S-J Tsai… in Molecular Psychiatry (2018)