45 Result(s)

Article

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by RAS mutations^1,2. RMC-7977 is a highly selective inhibitor of the active GTP-...

Urszula N. Wasko, **g**g Jiang, Tanner C. Dalton, Alvaro Curiel-Garcia… in Nature (2024)

Article

Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou… in Nature Communications (2023)

Article

Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer

Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier ca...

Ana Babic, Michael H. Rosenthal, Tilak K. Sundaresan… in Nature Communications (2023)

Article

A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories

Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes, indicating a pronounced need for early detection. In this study, we applied artificial intelligence methods to clinic...

Davide Placido, Bo Yuan, Jessica X. Hjaltelin, Chunlei Zheng… in Nature Medicine (2023)

Article

Pancreatic cancer is associated with medication changes prior to clinical diagnosis

Patients with pancreatic ductal adenocarcinoma (PDAC) commonly develop symptoms and signs in the 1–2 years before diagnosis that can result in changes to medications. We investigate recent medication changes a...

Yin Zhang, Qiao-Li Wang, Chen Yuan, Alice A. Lee, Ana Babic… in Nature Communications (2023)

Article

RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Recently developed inhibitors of polymerase theta (POLθ) have demonstrated synthetic lethality in BRCA-deficient tumor models. To examine the contribution of the immune microenvironment to antitumor efficacy, ...

Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou… in Nature Communications (2023)

Article

Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma

The mutant IDH1 inhibitor ivosidenib improves outcomes for patients with IDH1-mutated cholangiocarcinoma, but resistance inevitably develops. Mechanisms of resistance and strategies to overcome resistance are poo...

James M. Cleary, Betty Rouaisnel, Antoine Daina… in npj Precision Oncology (2022)

Article

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...

Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso… in Genome Medicine (2021)

Article

Acid-suppressive medications and risk of colorectal cancer: results from three large prospective cohort studies

Despite several plausible biological mechanisms linking proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) with colorectal tumorigenesis, their association with risk of colorectal cancer (CRC) h...

Ana Babic, Xuehong Zhang, Vicente Morales-Oyarvide, Chen Yuan… in British Journal of Cancer (2020)

Article

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-ex...

James M. McFarland, Brenton R. Paolella, Allison Warren… in Nature Communications (2020)

Article

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data ...

Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang… in Nature Communications (2020)

Article

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma

Background In pancreatic ductal adenocarcinoma (PDAC), the chemokine (C-C motif) ligand 2 (CCL2)/chemokine (C-C motif) receptor 2 (CCR2) axis plays a key role in immunosuppressive properties of the tumor microenv...

Marcus Noel, Eileen M. O’Reilly, Brian M. Wolpin… in Investigational New Drugs (2020)