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IL-8 and p53 are inversely regulated through JNK, p38 and NF-κB p65 in HepG2 cells during an inflammatory response

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    Open Access

    Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

    Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time o...

    Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder… in Nature Communications (2018)

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