66 Result(s)
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Article
Ben Ep**er
Medical Microbiology
Microbiology
Virology
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Article
Open AccessMicrobial polyphenol metabolism is part of the thawing permafrost carbon cycle
With rising global temperatures, permafrost carbon stores are vulnerable to microbial degradation. The enzyme latch theory states that polyphenols should accumulate in saturated peatlands due to diminished phe...
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Open AccessSubstantial viral diversity in bats and rodents from East Africa: insights into evolution, recombination, and cocirculation
Zoonotic viruses cause substantial public health and socioeconomic problems worldwide. Understanding how viruses evolve and spread within and among wildlife species is a critical step when aiming for proactive...
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Open AccessStructural insights into the mechanism of protein transport by the Type 9 Secretion System translocon
Secretion systems are protein export machines that enable bacteria to exploit their environment through the release of protein effectors. The Type 9 Secretion System (T9SS) is responsible for protein export ac...
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Open AccessA conserved interdomain microbial network underpins cadaver decomposition despite environmental variables
Microbial breakdown of organic matter is one of the most important processes on Earth, yet the controls of decomposition are poorly understood. Here we track 36 terrestrial human cadavers in three locations an...
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SARS-CoV-2 evolution in the Omicron era
Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages,...
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Open AccessDNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages
Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. H...
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Open AccessEukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation
The order Corynebacteriales includes major industrial and pathogenic Actinobacteria such as Corynebacterium glutamicum or Mycobacterium tuberculosis. These bacteria have multi-layered cell walls composed of the m...
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Open AccessLower viral evolutionary pressure under stable versus fluctuating conditions in subzero Arctic brines
Climate change threatens Earth’s ice-based ecosystems which currently offer archives and eco-evolutionary experiments in the extreme. Arctic cryopeg brine (marine-derived, within permafrost) and sea ice brine,...
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Open AccessA synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge
Typically, animal models studying gastrointestinal microbiotas compromised in early life have employed either germ-free animals or mice treated with a cocktail of antibiotics. Such studies intend to mimic scen...
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Open AccessSynthase-selected sorting approach identifies a beta-lactone synthase in a nudibranch symbiotic bacterium
Nudibranchs comprise a group of > 6000 marine soft-bodied mollusk species known to use secondary metabolites (natural products) for chemical defense. The full diversity of these metabolites and whether symbiot...
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Open AccessBabesia duncani multi-omics identifies virulence factors and drug targets
Babesiosis is a malaria-like disease in humans and animals that is caused by Babesia species, which are tick-transmitted apicomplexan pathogens. Babesia duncani causes severe to lethal infection in humans, but de...
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Open AccessMycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection
Mycobacteriophages are a diverse group of viruses infecting Mycobacterium with substantial therapeutic potential. However, as this potential becomes realized, the molecular details of phage infection and mechanis...
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Anaerobic methanotroph ‘Candidatus Methanoperedens nitroreducens’ has a pleomorphic life cycle
‘Candidatus Methanoperedens’ are anaerobic methanotrophic (ANME) archaea with global importance to methane cycling. Here meta-omics and fluorescence in situ hybridization (FISH) were applied to characterize a bio...
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Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism
Pharmaceuticals have extensive reciprocal interactions with the microbiome, but whether bacterial drug sensitivity and metabolism is driven by pathways conserved in host cells remains unclear. Here we show tha...
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Author Correction: Characteristics of SARS-CoV-2 and COVID-19
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Open AccessMetaPop: a pipeline for macro- and microdiversity analyses and visualization of microbial and viral metagenome-derived populations
Microbes and their viruses are hidden engines driving Earth’s ecosystems from the oceans and soils to humans and bioreactors. Though gene marker approaches can now be complemented by genome-resolved studies of...
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Dimethyl sulfide mediates microbial predator–prey interactions between zooplankton and algae in the ocean
Phytoplankton are key components of the oceanic carbon and sulfur cycles1. During bloom events, some species can emit large amounts of the organosulfur volatile dimethyl sulfide (DMS) into the ocean and consequen...
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Open AccessSuccessional dynamics and alternative stable states in a saline activated sludge microbial community over 9 years
Microbial communities in both natural and applied settings reliably carry out myriads of functions, yet how stable these taxonomically diverse assemblages can be and what causes them to transition between stat...
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Genetic Mutation of SARS-CoV-2 during Consecutive Passages in Permissive Cells
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SARS-CoV-2 variants, spike mutations and immune escape
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect...
