222 Result(s)
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Article
Open AccessGenome-wide atlas of rust resistance loci in wheat
Rust diseases, including leaf rust, stripe/yellow rust, and stem rust, significantly impact wheat (Triticum aestivum L.) yields, causing substantial economic losses every year. Breeding and deployment of cultivar...
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Open AccessNanosilver-based materials as feed additives: Evaluation of their transformations along in vitro gastrointestinal digestion in pigs and chickens by using an ICP-MS based analytical platform
The use of a new nanomaterial in the feed chain requires a risk assessment that involves in vitro gastrointestinal digestions to predict its degradation and oral exposure to nanoparticles. In this study, a nan...
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Open AccessRevealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Acid-sensing ion channels (ASICs) are trimeric proton-gated cation channels that play a role in neurotransmission and pain sensation. The snake venom-derived peptides, mambalgins, exhibit potent analgesic effe...
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Open AccessACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...
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Open AccessInhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation
Ionising radiation (IR) is widely used in cancer treatment, including for head and neck squamous cell carcinoma (HNSCC), where it induces significant DNA damage leading ultimately to tumour cell death. Among t...
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Open AccessEgg White Hydrolysate Mitigates Cadmium-induced Neurological Disorders and Oxidative Damage
We aimed to investigate whether the consumption of Egg White Hydrolysate (EWH) acts on nervous system disorders induced by exposure to Cadmium (Cd) in rats. Male Wistar rats were divided into (a) Control (Ct): H2
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Open AccessOntogeny and social context regulate the circadian activity patterns of Lake Malawi cichlids
Activity patterns tend to be highly stereotyped and critical for executing many different behaviors including foraging, social interactions, and predator avoidance. Differences in the circadian timing of locom...
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Open AccessCorrection: Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14
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Open AccessDynamic changes in RNA m6A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation
RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications regulate the innate immune response, their role in monocyte-to-macropha...
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Open AccessHealthcare Utilization Patterns: Irritable Bowel Syndrome, Inflammatory Bowel Disease, and Gastroesophageal Reflux Disease
Limited information is available about patterns of healthcare utilization for prevalent gastrointestinal conditions and their link to symptom burden.
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Open AccessDevelopment and Validation of a Colorectal Cancer Prediction Model: A Nationwide Cohort-Based Study
Early diagnosis of colorectal cancer (CRC) is critical to increasing survival rates. Computerized risk prediction models hold great promise for identifying individuals at high risk for CRC. In order to utilize...
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Open AccessFlotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14
Lipopolysaccharide (LPS) induces a strong pro-inflammatory reaction of macrophages upon activation of Toll-like receptor 4 (TLR4) with the assistance of CD14 protein. Considering a key role of plasma membrane ...
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Open AccessEnhancing Pisum sativum growth and symbiosis under heat stress: the synergistic impact of co-inoculated bacterial consortia and ACC deaminase-lacking Rhizobium
The 1-aminocyclopropane-1-carboxylate (ACC) deaminase is a crucial bacterial trait, yet it is not widely distributed among rhizobia. Hence, employing a co-inoculation approach that combines selected plant grow...
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Open AccessAtmospheric Degradation of Ecologically Important Biogenic Volatiles: Investigating the Ozonolysis of (E)-β-Ocimene, Isomers of α and β-Farnesene, α-Terpinene and 6-Methyl-5-Hepten-2-One, and Their Gas-Phase Products
Biogenic volatile organic compounds (bVOCs), synthesised by plants, are important mediators of ecological interactions that can also undergo a series of reactions in the atmosphere. Ground-level ozone is a sec...
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Open AccessSelective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo
During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emer...
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Open AccessAssessing the potential of genetic resource introduction into elite germplasm: a collaborative multiparental population for flint maize
Implementing a collaborative pre-breeding multi-parental population efficiently identifies promising donor x elite pairs to enrich the flint maize elite germplasm.
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Open AccessTargeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells
Regulatory T cells (Tregs) are a key determinant for the immunosuppressive and premetastatic niche for cancer progression after surgery resection. However, the precise mechanisms regulating Tregs function duri...
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Open AccessRecombination-mediated dissemination of Methicillin-resistant S. aureus clonal complex 1 in the Egyptian health care settings
Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly evolving pathogen that is frequently associated with outbreaks and sustained epidemics. This study investigated the population structure, resistome,...
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Open AccessMyeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue and leads to elevated cytokines such as interleukin-1β (IL-1β) in the circulation and ti...
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Open AccessThe mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment
Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four groups defined by molecular characteristics, Group 3, the least well characterized, is also the least favorable, with a s...
