14 Result(s)

Article

NMR in integrated biophysical drug discovery for RAS: past, present, and future

Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase domain and a C-terminal lipid-modified tail that is uni...

Christopher B. Marshall, Fenneke KleinJan… in Journal of Biomolecular NMR (2020)

Article

NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei

The presence of suitable cavities or pockets on protein structures is a general criterion for a therapeutic target protein to be classified as ‘druggable’. Many disease-related proteins that function solely th...

Stefan Nebl, Wesam S. Alwan, Martin L. Williams… in Journal of Biomolecular NMR (2020)

Article

¹H, ¹³C, and ¹⁵N backbone resonance assignments for KPC-2, a class A serine-β-lactamase

The ever-increasing occurrence of antibiotic resistance presents a major threat to public health. Specifically, resistance conferred by β-lactamases places the efficacy of currently available antibiotics at ri...

Jamie VanPelt, Ben A. Shurina, Theresa A. Ramelot… in Biomolecular NMR Assignments (2019)

Article

Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels

There is clear evidence that the net magnitude of negative charge at the intracellular end of inwardly rectifying potassium channels helps to generate an asymmetry in the magnitude of the current that will pas...

Tamsyn A. Hilder, Ben Corry, Shin-Ho Chung in Journal of Biological Physics (2014)

Article

Backbone ¹H, ¹³C, and ¹⁵N chemical shift assignment for HIV-1 protease subtypes and multi-drug resistant variant MDR 769

HIV-1 protease (HIV-1PR) is an essential drug target in the treatment of patients infected with HIV-1. Mutations are found to arise in over 38 of 99 amino acid sites in this protein in response to drug therapy...

** Huang, Ian Mitchelle S. de Vera, Angelo M. Veloro… in Biomolecular NMR Assignments (2013)

Article

¹H, ¹³C, and ¹⁵N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum

Phosphoethanolamine methyltransferases (PMTs also known as PEAMTs) catalyze the three-step s-adenosyl-methionione-dependent methylation of phosphoethanolamine to form phosphocholine. These enzymes play an impo...

Irina Bezsonova, Iulian Rujan, April M. Bobenchik… in Biomolecular NMR Assignments (2013)

Article

Glutamate regulation of calcium and IP₃ oscillating and pulsating dynamics in astrocytes

Recent years have witnessed an increasing interest in neuron–glia communication. This interest stems from the realization that glia participate in cognitive functions and information processing and are involve...

Maurizio De Pittà, Mati Goldberg, Vladislav Volman… in Journal of Biological Physics (2009)

Article

Sequence specific ¹H, ¹³C and¹⁵ N resonance assignment of rat CD2 domain 1

Ho A. Chen, Mark Pfuhl, Ben Davis, Paul C. Driscoll in Journal of Biomolecular NMR (1998)

Article

An approach to global fold determination using limited NMR data from larger proteins selectively protonated at specific residue types

A combination of calculation and experiment is used to demonstrate that the global fold of larger proteins can be rapidly determined using limited NMR data. The approach involves a combination of heteronuclear...

Brian O. Smith, Yutaka Ito, Andrew Raine, Sarah Teichmann… in Journal of Biomolecular NMR (1996)

Article

Wave-separation in complex systems. Application to brain-signals

A departure from single-system dynamics, that may arise in characterizing self-organized dynamics of complex systems, is dealt with by using the Karhunen-Loève expansion of the trajectory matrix to decompose a...

R. Cerf, M. Ould Hénoune, M. L. Ben Matti, E. H. El Ousdad… in Journal of Biological Physics (1993)