66 Result(s)
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Chemistry
Biochemistry, general
Physical Chemistry
Ben Ep**er
Article
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Article
Photosensitization of Colpoda inflata cysts bymeso-substituted cationic porphyrins
Colpoda inflata cysts accumulate significantly large amounts ofmeso-substituted cationic porphyrins, includingmeso-tetrakis(N-methyl-4-pyridyl)porphine (TMP-C1) and its mono-N-methyldecyl (TMP-C10) and -tetradecy...
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Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder
Photodynamic therapy (PDT) involves the local or systemic administration of a photosensitizing drug that, upon light irradiation and presence of oxygen, results in tissue damage such as tumor destruction. Hype...
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GPCRs as therapeutic targets: a view on adenosine receptors structure and functions, and molecular modeling support
G-protein-coupled receptors (GPCRs) represent the largest known family of signal-transducing proteins and transmit signals for light and many extracellular regulatory molecules. GPCRs are dysfunctional or dysr...
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Photosynthesis: a blueprint for solar energy capture and biohydrogen production technologies
Solar energy capture, conversion into chemical energy and biopolymers by photoautotrophic organisms, is the basis for almost all life on Earth. A broad range of organisms have developed complex molecular machi...
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Solving the structure of plant photosystem I—biochemistry is vital
The recently determined structure of plant photosystem I (PSI) provides the first relatively high-resolution structural model of a supercomplex containing a reaction center and its peripheral antenna. Large am...
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Regulation of aerobic photosystem synthesis in the purple bacterium Rhodospirillum centenum by CrtJ and AerR
Genes coding for putative CrtJ and AerR homologs were identified and characterized in the purple photosynthetic bacterium Rhodospirillum centenum (also known as Rhodocista centenaria), an organism that synthesize...
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The localization and photosensitization of modified chlorin photosensitizers in artificial membranes
In this work we investigate the localization and photophysical properties of twelve synthetically derivedchlorins in artificial membranes, with the goal of designing more effective photosensitizers for photody...
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Springing into action
Controlling the movements of molecular systems through external stimuli is crucial for the construction of nanoscale mechanical machines. A spring-like compound has now been prepared — a double helicate that r...
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Catalytic enantioselective syn hydration of enones in water using a DNA-based catalyst
The enantioselective addition of water to olefins in an aqueous environment is a common transformation in biological systems, but was beyond the ability of synthetic chemists. Here, we present the first exampl...
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Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids
Hypericin is a bright red fluorescent compound that can be used in urological medicine as a photodiagnostic to detect non-muscle-invasive bladder cancer lesions. To this end a bladder instillation fluid is pre...
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Reversing the direction in a light-driven rotary molecular motor
Biological rotary motors can alter their mechanical function by changing the direction of rotary motion. Achieving a similar reversal of direction of rotation in artificial molecular motors presents a fundamen...
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Catalytic asymmetric carbon–carbon bond formation via allylic alkylations with organolithium compounds
Carbon–carbon bond formation is the basis for the biogenesis of nature's essential molecules. Consequently, it lies at the heart of the chemical sciences. Chiral catalysts have been developed for asymmetric C–...
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The final frontier
Cross-coupling between a racemic secondary alkyl halide and an alkyl borane to produce an enantioenriched alkyl–alkyl product is one of the final substrate combinations to succumb to the synthetically powerful...
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Fuelling movement at the nanoscale
Autonomous propulsion of microparticles using catalytic olefin polymerization, and directional rotation of a molecule on a metal surface using electrons from the tip of a scanning tunnelling microscope.
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Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids
The redesign of enzymes to produce catalysts for a predefined transformation remains a major challenge in protein engineering. Here, we describe the structure-based engineering of methylaspartate ammonia lyase...
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Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals
The solubility characteristics of 40–70% of new drug candidates are so poor that they cannot be formulated on their own, so new methods for increasing drug solubility are highly prized. Here, we describe a new...
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Ultrafast dynamics in the power stroke of a molecular rotary motor
Light-driven molecular motors convert light into mechanical energy through excited-state reactions. Unidirectional rotary molecular motors based on chiral overcrowded alkenes operate through consecutive photoc...
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Serum 25-hydroxyvitamin-D responses to multiple UV exposures from solaria: inferences for exposure to sunlight
We investigate the relationship between blood serum 25-hydroxyvitamin D (25(OH)D) and UV exposure from two artificial sources. We then use the results to test the validity of the action spectrum for vitamin D ...
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Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading
Virus-like particles (VLPs) have emerged as important and versatile architectures for chemical manipulation in the development of functional hybrid nanostructures. Here we demonstrate a successful site-selecti...
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Direct catalytic cross-coupling of organolithium compounds
Catalytic carbon–carbon bond formation based on cross-coupling reactions plays a central role in the production of natural products, pharmaceuticals, agrochemicals and organic materials. Coupling reactions of ...
