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  1. No Access

    Article

    Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study

    Recently, cytokine gene transfer into tumour cells has been shown to mediate tumour regression in animal models via immunomodulation. Consequently, a number of clinical protocols have been developed to treat c...

    P Möller, Y Sun, T Dorbic, S Alijagic, A Makki, K Jurgovsky… in British Journal of Cancer (1998)

  2. Article

    Open Access

    Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma

    Natural killer-like T lymphocytes termed cytokine-induced killer (CIK) cells have been shown to eradicate established tumours in a severe combined immune deficient (SCID) mouse/human lymphoma model. Recently, ...

    I G H Schmidt-Wolf, S Finke, B Trojaneck, A Denkena… in British Journal of Cancer (1999)

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