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  1. No Access

    Article

    A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of α2 integrin inhibitor E7820 in patients with advanced solid tumors

    Introduction E7820 is an orally administered sulfonamide that inhibits alfa-2-integrin mRNA expression. Pre-clinically E7820 showed tumor anti-angiogenic effects in various tumor cell lin...

    B. Milojkovic Kerklaan, S. Slater, M. Flynn, A. Greystoke… in Investigational New Drugs (2016)

  2. Article

    Open Access

    Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours

    This phase I study evaluated the safety, tolerability, maximum tolerated dose (MTD) and pharmacokinetics of two dosing schedules of oral topotecan in combination with pazopanib in patients with advanced solid ...

    B Milojkovic Kerklaan, M P J Lolkema, L A Devriese, E E Voest… in British Journal of Cancer (2015)

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