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  1. Article

    Open Access

    A novel pathway of levodopa metabolism by commensal Bifidobacteria

    The gold-standard treatment for Parkinson’s disease is levodopa (L-DOPA), which is taken orally and absorbed intestinally. L-DOPA must reach the brain intact to exert its clinical effect; peripheral metabolism...

    M. S. Cirstea, A. Creus-Cuadros, C. Lo, A. C. Yu, A. Serapio-Palacios… in Scientific Reports (2023)

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  2. Article

    Open Access

    Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition

    Child undernutrition is a global health issue associated with a high burden of infectious disease. Undernourished children display an overabundance of intestinal pathogens and pathobionts, and these bacteria i...

    K. E. Huus, T. T. Hoang, A. Creus-Cuadros, M. Cirstea, S. L. Vogt… in Nature Communications (2021)

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  3. No Access

    Article

    Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body

    The authors report the structure of the assembled membrane spanning ring forming proteins of the Salmonella Typhimurium injectisome basal body, including the first atomic structure of a member of the secretin fam...

    L. J. Worrall, C. Hong, M. Vuckovic, W. Deng, J. R. C. Bergeron, D. D Majewski… in Nature (2016)

  4. No Access

    Article

    Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease

    Polymorphic variants within the human natural resistance-associated macrophage protein-1 (NRAMP1, also known as SLC11A1) gene have been shown to impact on susceptibility to tuberculosis in different human populat...

    C J Gallant, S Malik, N Jabado, M Cellier, L Simkin, B B Finlay… in Genes & Immunity (2007)

  5. No Access

    Article

    Enteropathogenic Escherichia coli: a pathogen that inserts its own receptor into host cells

    Enteropathogenic Escherichia coli (EPEC) is a major cause of infant diarrhea, killing hundreds of thousands of children per year worldwide. Intimate attachment to the host cell leading to the formation of actin-...

    R. DeVinney, A. Gauthier, A. Abe, B. B. Finlay in Cellular and Molecular Life Sciences CMLS (1999)