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Article
Evidence for a pleiotropic QTL on chromosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families
Although many genome screens have been conducted for asthma as a binary trait, there is limited information regarding the genetic factors underlying variation of asthma expression. Phenotypes related to variab...
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Article
Open AccessComparing single-nucleotide polymorphism marker-based and microsatellite marker-based linkage analyses
We compared linkage analysis results for an alcoholism trait, ALDX1 (DSM-III-R and Feigner criteria) using a nonparametric linkage analysis method, which takes into account allele sharing among several affecte...
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Article
Open AccessCorrelation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects
We address the question of whether statistical correlations among quantitative traits lead to correlation of linkage results of these traits. Five measured quantitative traits (total cholesterol, fasting gluco...
