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Article
Phyllodes Tumors of the Breast—Experience in a Tertiary Care Center
Phyllodes tumors (PTs) are rare neoplasms of the breast that are a challenge in clinical practice. Though mostly benign, they are notorious for local recurrence, requiring adjuvant treatments. This study was p...
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Article
Open AccessTrajectories of cardiac troponin in the decades before cardiovascular death: a longitudinal cohort study
High-sensitivity cardiac troponin testing is a promising tool for cardiovascular risk prediction, but whether serial testing can dynamically predict risk is uncertain. We evaluated the trajectory of cardiac tr...
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Article
Open AccessMachine learning for diagnosis of myocardial infarction using cardiac troponin concentrations
Although guidelines recommend fixed cardiac troponin thresholds for the diagnosis of myocardial infarction, troponin concentrations are influenced by age, sex, comorbidities and time from symptom onset. To imp...
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Article
Serum transthyretin and risk of cognitive decline and dementia: 22-year longitudinal study
Serum transthyretin (TTR) may be an early biomarker for Alzheimer’s disease and related disorders (ADRD). We investigated associations of TTR measured at baseline with cognitive decline and incident ADRD and w...
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Article
Open AccessDiagnostic performance of the combined nasal and throat swab in patients admitted to hospital with suspected COVID-19
Accurate diagnosis in patients with suspected coronavirus disease 2019 (COVID-19) is essential to guide treatment and limit spread of the virus. The combined nasal and throat swab is used widely, but its diagn...
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Article
Open AccessFrailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction
Risk prediction after myocardial infarction is often complex in older patients. The Global Registry of Acute Coronary Events (GRACE) model includes clinical parameters and age, but not frailty. We hypothesised...
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Article
Open AccessDelirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method
Delirium affects > 15% of hospitalised patients but is grossly underdetected, contributing to poor care. The 4 ‘A’s Test (4AT, www.the4AT.com) is a short del...
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Article
Terpene profiling, transcriptome analysis and characterization of cis-β-terpineol synthase from Ocimum
Ocimum species produces a varied mix of different metabolites that imparts immense medicinal properties. To explore this chemo-diversity, we initially carried out metabolite profiling of different tissues of five...
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Article
Anthelmintic efficacy of aqueous extract of Zanthoxylum armatum DC. seeds against Haemonchus contortus of small ruminants
Haemonchus contortus infection is the major hurdle in growth and productivity in small ruminants especially in tropical countries. Indiscriminate and long term use of currently available ...
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Article
Open AccessPotential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights
Medicinally important genus Ocimum harbors a vast pool of chemically diverse metabolites. Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. Major metabolites in O. kilimands...
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Article
In-vitro Anthelmintic Efficacy of Aqueous Extract of Scindapsus officinalis (Roxb.) Schott Fruits Against Haemonchus contortus of Small Ruminants
Haemonchus contortus infection in small ruminants is one of the most important causes of reduced growth, mortality of young ones and decreased reproduction of adults. Non-availability of selectiv...
