6 Result(s)
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Article
An-Yuan Guo
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMulti-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy
Autophagy is a major contributor to anti-cancer therapy resistance. Many efforts have been made to understand and overcome autophagy-mediated therapy resistance, but these efforts have been unsuccessful in cli...
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Article
Open AccessAblation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy
Mutations in EYS are associated with autosomal recessive retinitis pigmentosa (arRP) and autosomal recessive cone-rod dystrophy (arCRD) however, the function of EYS and the molecular mechanisms of how these mutat...
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Article
Open AccessLoss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis
Disseminated superficial porokeratosis (DSP) is a rare keratinization disorder of the epidermis. It is characterized by keratotic lesions with an atrophic center encircled by a prominent peripheral ridge. We i...
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Article
Open AccessTranscription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell
The maturation process of lymphocyte was related to many blood diseases, such as lymphoma and lymphoid leukemia. Many TFs and miRNAs were separately studied in the development of B and T cells. In this study, ...
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Article
Open AccessScoring the correlation of genes by their shared properties using OScal, an improved overlap quantification model
Scoring the correlation between two genes by their shared properties is a common and basic work in biological study. A prospective way to score this correlation is to quantify the overlap between the two sets ...
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Article
Open AccessMiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction
Myocardial infarction (MI) is a leading cause of death in the world and many genes are involved in it. Transcription factor (TFs) and microRNAs (miRNAs) are key regulators of gene expression. We hypothesized t...
