4 Result(s)

Article

Author Correction: Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

J. James E. Barrett, Chiara Herzog, Yoo-Na Kim, Thomas E. Bartlett… in Genome Biology (2022)

Article

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Wheth...

James E. Barrett, Chiara Herzog, Yoo-Na Kim, Thomas E. Bartlett… in Genome Biology (2022)

Article

Stochastic epigenetic outliers can define field defects in cancer

There is growing evidence that DNA methylation alterations may contribute to carcinogenesis. Recent data also suggest that DNA methylation field defects in normal pre-neoplastic tissue represent infrequent sto...

Andrew E. Teschendorff, Allison Jones, Martin Widschwendter in BMC Bioinformatics (2016)

Article

An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer

One of the most important recent findings in cancer genomics is the identification of novel driver mutations which often target genes that regulate genome-wide chromatin and DNA methylation marks. Little is kn...

Zhen Yang, Allison Jones, Martin Widschwendter, Andrew E. Teschendorff in Genome Biology (2015)