5 Result(s)
within
Article
Akihiko Tsuji
-
Article
Open AccessPCTK3/CDK18 regulates cell migration and adhesion by negatively modulating FAK activity
PCTAIRE kinase 3 (PCTK3) is a member of the cyclin dependent kinase family, but its physiological function remains unknown. We previously reported that PCTK3-knockdown HEK293T cells showed actin accumulation a...
-
Article
Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells
Estrogenic compounds include endogenous estrogens such as estradiol as well as soybean isoflavones, such as daidzein and its metabolite equol, which are known phytoestrogens that prevent osteoporosis in postme...
-
Article
Structural and biochemical studies on Pompe disease and a “pseudodeficiency of acid α-glucosidase”
We constructed structural models of the catalytic domain and the surrounding region of human wild-type acid α-glucosidase and the enzyme with amino acid substitutions by means of homology modeling, and examine...
-
Article
Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system
PACE4 is a mammalian Kexin family protease that is involved in the maturation of precursor proteins. Four PACE4 isoforms have been identified. We identified a novel PACE4 isoform, PACE4E, from a human cerebel...
-
Article
Galactosialidosis: molecular heterogeneity in biosynthesis and processing of protective protein for β-galactosidase
Biosynthesis and processing of the protective protein for β-galactosidase in normal and galactosialidosis fibroblasts were investigated using specific antiserum preparations. A 45-kd precursor was processed to...
