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  1. No Access

    Article

    DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway

    Alzheimer’s disease (AD) is a worldwide problem and there are no effective drugs for AD treatment. Previous studies show that DL0410 is a multi-target, anti-AD agent. In this study, we investigated the therape...

    Wen-wen Lian, Wei Zhou, Bao-yue Zhang, Hao Jia, Lv-jie Xu… in Acta Pharmacologica Sinica (2021)

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    Article

    DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

    At present, few available drugs can be used to either improve pathological features or prevent the progression of Alzheimer’s disease (AD). DL0410 ((1,1′-([1,1′-biphenyl]-4,4′-diyl) bis (3-(piperidin-1-yl) propan...

    Wei Zhou, Wen-wen Lian, Rong Yan, Hao Jia, Lv-jie Xu… in Acta Pharmacologica Sinica (2020)

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    Article

    Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth

    Host cdc2-like kinase 1 (CLK1) is responsible for the alternative splicing of the influenza virus M2 gene during influenza virus infection and replication that has been recognized as a potential anti-influenza...

    Chao Li, Lv-jie Xu, Wen-wen Lian, **ao-cong Pang, Hao Jia… in Acta Pharmacologica Sinica (2018)

  4. Article

    DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway

    1,1′-([1,1′-Biphenyl]-4,4′-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride (DL0410) is a novel synthetic dual acetylcholinesterase (AChE)/butyrocholinesterase (BuChE) inhibitor, which has shown a poten...

    Dan Zhou, Wei Zhou, Jun-ke Song, Zhang-ying Feng… in Acta Pharmacologica Sinica (2016)

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  5. Article

    Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis

    This study was designed to investigate whether the activation of the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway is required for thermal preconditioning to protect rat cerebellar granule neurons (CGN) ag...

    Lin Cao, De-xiong Cao, **ng-wen Su, Li-jun Chen, Ai-lin Liu… in Acta Pharmacologica Sinica (2007)

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