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Article
α-Synuclein strains target distinct brain regions and cell types
The clinical and pathological differences between synucleinopathies such as Parkinson’s disease and multiple system atrophy have been postulated to stem from unique strains of α-synuclein aggregates, akin to w...
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Article
Open AccessPrion-like propagation of β-amyloid aggregates in the absence of APP overexpression
The amyloid cascade hypothesis posits that the initiating event in Alzheimer’s disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amylo...