63 Result(s)
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Article
Developmental changes of NADPH-diaphorase positive structures in the isthmic nuclei of the chick
Nicotine adenine dinucleotide phosphate-dia- phorase staining was used to study nitric oxide synthase activity and distribution in the midbrain visual structures of white leghorn chick embryos and post-hatched...
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Article
Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection
The use of exogenous cytokines is part of translational immune-antiretroviral approaches to induce immune reconstitution and possibly eliminate the persistence of human immunodeficiency virus type 1 (HIV-1) in...
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Article
Modulation of γ-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats
To observe the effects of γ-aminobutyric acid (GABA) on the electric activities of pain-excited neurons (PEN) in nucleus accumbens (NAc) in central nervous system (CNS) of morphine-dependent rats.
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Article
NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis
Recently, neutrophil gelatinase-associated lipocalin (NGAL) and its cell surface receptor, NGALR, have been shown to have critical roles in the biology of various tumors. Therefore, we investigated the express...
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Open AccessIsoflurane does not cause neuroapoptosis but reduces astroglial processes in young adult mice
Isoflurane, a volatile anesthetic widely used clinically, has been implicated to be both neuroprotective and neurotoxic. The claim about isoflurane causing neural apoptosis remains controversial. In this study...
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Article
Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction
Spinal cord injury is associated with rapid bone loss and arrested long bone growth due to mechanisms that are poorly understood. In this study, we sought to determine the effects of severe T10 contusion spina...
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Aspirin Protects Dopaminergic Neurons Against Lipopolysaccharide-Induced Neurotoxicity in Primary Midbrain Cultures
Aspirin (ASA) is one of the most widely used nonsteroidal anti-inflammatory drugs. ASA has primarily been used to treat headaches, rheumatic pain, and inflammation, but its therapeutic effects have recently be...
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Article
Long-term efficacy of autologous haematopoietic stem cell transplantation in multiple sclerosis at a single institution in China
Autologous haematopoietic stem cell transplantation (AHSCT) is a promising treatment for multiple sclerosis (MS) patients who have not adequately responded to conventional therapies. We retrospectively evaluat...
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Article
Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta
Neuromyelitis optica (NMO) is an antibody-mediated disease with the target antigen being the water channel aquaporin-4 (AQP4). More than 90% of NMO patients have relapse. Optimal treatments to prevent recurren...
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Article
Increased Levels of Monoamine-Derived Potential Neurotoxins in Fetal Rat Brain Exposed to Ethanol
Pregnant SD rats were exposed to ethanol (25 % (v/v) ethanol at 1.0, 2.0 or 4.0 g/kg body weight from GD8 to GD20) to assess whether ethanol-derived acetaldehyde could interact with endogenous monoamine to gen...
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Article
Prefrontal Control of Cerebellum-Dependent Associative Motor Learning
Behavioral studies have demonstrated that both medial prefrontal cortex (mPFC) and cerebellum play critical roles in trace eyeblink conditioning. However, little is known regarding the mechanism by which the t...
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Article
Open AccessNovel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins
The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) refe...
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Article
Open AccessmicroRNA-128a dysregulation in transgenic Huntington’s disease monkeys
Huntington’s Disease (HD) is a progressive neurodegenerative disorder with a single causal mutation in the Huntingtin (HTT) gene. MicroRNAs (miRNAs) have recently been implicated as epigenetic regulators of neuro...
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Article
Open AccessMet-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection
Infection of rabies virus (RABV) causes central nervous system (CNS) dysfunction and results in high mortality in human and animals. However, it is still unclear whether and how CNS inflammation and immune res...
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Open AccessThe problem of axonal injury in the brains of veterans with histories of blast exposure
Blast injury to brain, a hundred-year old problem with poorly characterized neuropathology, has resurfaced as health concern in recent deployments in Iraq and Afghanistan. To characterize the neuropathology of...
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Article
Open AccessSexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy
Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of motor and cognitive impairment in children. Clinically, male infants are more vulnerable to ischemic insults and suffer more long-term de...
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Article
Prestroke glycemic status is associated with the functional outcome in spontaneous intracerebral hemorrhage
Admission hyperglycemia is thought to be related to poor neurological function and high mortality in patients with spontaneous intracerebral hemorrhage (sICH). However, it is not known whether prestroke glycem...
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Article
Open AccessGranulomatous hypophysitis: experience with eight surgical cases of a single center
Although primary hypophysitis is not uncommon, a granulomatous etiology of hypophysitis is relatively rare. Radiological and diagnostic characteristics of several isolated cases have been described to date. Ho...
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ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation
Glioblastoma (GBM) is the most common primary malignant brain tumor. Microvascular proliferation is one of the characteristic pathologic features of GBM. Mitochondrial dysfunction plays an important role in th...
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PreSurgMapp: a MATLAB Toolbox for Presurgical Map** of Eloquent Functional Areas Based on Task-Related and Resting-State Functional MRI
The main goal of brain tumor surgery is to maximize tumor resection while minimizing the risk of irreversible postoperative functional sequelae. Eloquent functional areas should be delineated preoperatively, p...
