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  1. Article

    Open Access

    Constructing diagnostic signature of serum microRNAs using machine learning for early pan-cancer detection

    Cancer is a major public health concern and the second leading cause of death worldwide. Various studies have reported the use of serum microRNAs (miRNAs) as non-invasive biomarkers for cancer detection. Howev...

    Yuyan Xu, Wei Liao, Huanwei Chen, Mingxin Pan in Discover Oncology (2024)

  2. No Access

    Article

    Relationship between changes in late-life blood pressure and the risk of frailty and mortality among older population in China: a cohort study based on CLHLS

    The evidence regarding the effects of blood pressure changes on older individuals remains inconclusive, and the impact of frailty throughout the life course is not known. We investigated the associations of di...

    Yana Chen, Yanfang Wang, Yan Xu, Shunyao Shi, Zhong Tian in Hypertension Research (2024)

  3. Article

    Open Access

    Personalized prediction of mortality in patients with acute ischemic stroke using explainable artificial intelligence

    Research into the acute kidney disease (AKD) after acute ischemic stroke (AIS) is rare, and how clinical features influence its prognosis remain unknown. We aim to employ interpretable machine learning (ML) mo...

    Lingyu Xu, Chenyu Li, Jiaqi Zhang, Chen Guan in European Journal of Medical Research (2024)

  4. No Access

    Article

    Melatonin inhibits circadian gene DEC1 and TLR2/MyD88/NF-κB signaling pathway to alleviate renal injury in type 2 diabetic mice

    Diabetic Kidney Disease (DKD) is a complex disease associated with circadian rhythm and biological clock regulation disorders. Melatonin (MT) is considered a hormone with renal protective effects, but its mech...

    Yan-Yan Xu, Tong Chen, Hong Ding, Qiong Chen, Qiu-Ling Fan in Acta Diabetologica (2024)

  5. Article

    Open Access

    Investigation of the anatomic risk factors in acute anterior cruciate ligament ruptures to develop ramp lesions of the medial meniscus by quantitative MRI

    To investigate the anatomic risk factors of knee in patients with acute non-contact anterior cruciate ligament (aACL) ruptures to develop ramp lesions.

    Ziyi Tang, Yuxi Luo, Dan Liu, Suying Zhou, Zhangyan Xu in Insights into Imaging (2024)

  6. Article

    Open Access

    Fluorescence in situ hybridization reveals the evolutionary biology of minor clone of gain/amp(1q) in multiple myeloma

    Growing evidence suggests that gain or amplification [gain/amp(1q)] accumulates during disease progression of multiple myeloma (MM). Previous investigations have indicated that small gain/amp(1q) subclones pre...

    Jian Cui, Yuntong Liu, Rui Lv, Wenqiang Yan, **gyu Xu, Lingna Li, Chenxing Du in Leukemia (2024)

  7. Article

    Open Access

    Novel SETBP1 D874V adjacent to the degron causes canonical schinzel–giedion syndrome: a case report and review of the literature

    Schinzel-Giedion syndrome (SGS) is a severe multisystem disorder characterized by distinctive facial features, profound intellectual disability, refractory epilepsy, cortical visual impairment, hearing loss, a...

    **g Zheng, Meiqun Gu, Shasha **ao, Chongzhen Li, Hongying Mi, **aoyan Xu in BMC Pediatrics (2024)

  8. No Access

    Article

    Obstructive sleep apnea in relation to beat-to-beat, reading-to-reading, and day-to-day blood pressure variability

    We investigated blood pressure (BP) variability as assessed by beat-to-beat, reading-to-reading and day-to-day BP variability indices in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). In 786 ...

    Yi-Bang Cheng, Qian-Hui Guo, Jia-Hui **a, ** Zhang, Ting-Yan Xu in Hypertension Research (2024)

  9. Article

    Open Access

    Risk factors for nonunion of osteoporotic vertebral compression fracture: a case‒control study

    Early assessment of the risk of nonunion in osteoporotic vertebral compression fracture (OVCF) is beneficial to early clinical decision making. However, a comprehensive understanding of the risk factors for OV...

    Shichuan Liao, Yan Xu, **g Liu, Ling Jiang, Guogang Dai in BMC Musculoskeletal Disorders (2024)

  10. Article

    Open Access

    Research advances of tissue-derived extracellular vesicles in cancers

    Extracellular vesicles (EVs) can mediate cell-to-cell communication and affect various physiological and pathological processes in both parent and recipient cells. Currently, extensive research has focused on ...

    Wei Li, **gyao Zhu, Jiayuan Li, Yiyun Jiang in Journal of Cancer Research and Clinical On… (2024)

  11. Article

    Open Access

    Efficacy and safety of oral ibrexafungerp in Chinese patients with vulvovaginal candidiasis: a phase III, randomized, double-blind study

    To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC).

    **aoqian Wang, Wenying Wang, **g**g Li, Ruifang An, Lihong Chen, Jia**g Lin in Infection (2024)

  12. Article

    Open Access

    Clinical characteristics and antimicrobial therapy of healthcare-associated carbapenem-non-susceptible gram-negative bacterial meningitis: a 16-year retrospective cohort study

    Healthcare-associated Gram-negative bacterial meningitis is a substantial clinical issue with poor outcomes, especially for neurosurgical patients. Here, we aimed to study the characteristics and treatment opt...

    Jiyan Xu, **aoling Du, Dan Li, Pei Li, Qinglan Guo, **aogang Xu in BMC Infectious Diseases (2024)

  13. Article

    Open Access

    Angiography-based hemodynamic features predict recurrent ischemic events after angioplasty and stenting of intracranial vertebrobasilar atherosclerotic stenosis

    To assess the predictive value of hemodynamic features for stroke relapse in patients with intracranial vertebrobasilar atherosclerotic stenosis treated with percutaneous transluminal angioplasty and stenting ...

    Kangmo Huang, Weihe Yao, Mingming Zha, Shanmei Qin, Yingle Li, Yan Xu in European Radiology (2024)

  14. No Access

    Article

    Volume reduction rate of radiofrequency ablation in ≤ 2 cm Bethesda IV thyroid nodules

    This prospective observational study aimed to evaluate the efficacy of radiofrequency ablation (RFA) in treating ≤ 2 cm thyroid nodules with Bethesda IV cytology and C-TIRADS 4A categorization. Additionally, t...

    YiJie Dong, WeiWei Zhan, JianQiao Zhou, Ning Li, ZhenHua Liu in European Radiology (2024)

  15. No Access

    Article

    Non-invasive left ventricular pressure-strain loop study on cardiac fibrosis in primary aldosteronism: a comparative study with cardiac magnetic resonance imaging

    We investigated the potential diagnostic value of the myocardial work indices based on speckle tracking echocardiography for cardiac fibrosis in patients with primary aldosteronism. Our observational study inc...

    Yi-Lin Chen, Chi-Hua Chen, Ting-Yan Xu, Jian-Zhong Xu, Li-Min Zhu in Hypertension Research (2024)

  16. Article

    Open Access

    Network pharmacology and experimental validation to study the potential mechanism of Tongguanteng injection in regulating apoptosis in osteosarcoma

    The main objectives of this study were to identify the active components of Tongguanteng injection (TGT) and investigate the preclinical efficacy and mechanism of TGT on osteosarcoma using a combination of net...

    Lanyi Wei, **g**g Meng, Danfeng **ang in BMC Complementary Medicine and Therapies (2024)

  17. Article

    Open Access

    Ultrasound had high accuracy in measuring hip joint capsule thickness

    The hip joint capsule is an essential component of hip joint function and stability, and its thickness is closely associated with certain medical conditions, surgical outcomes, and rehabilitation treatments. C...

    Guanying Gao, Huaan Fang, Kaicheng Zhou, Zizhi Mo in BMC Musculoskeletal Disorders (2024)

  18. Article

    Open Access

    Grating-based x-ray dark-field CT for lung cancer diagnosis in mice

    The low absorption of x-rays in lung tissue and the poor resolution of conventional computed tomography (CT) limits its use to detect lung disease. However, x-ray dark-field imaging can sense the scattered x-r...

    Peiyuan Guo, Li Zhang, **cheng Lu, Huitao Zhang in European Radiology Experimental (2024)

  19. Article

    Open Access

    Correction: Exploring the association between triglyceride-glucose index and thyroid function

    Hui Cheng, Yanyan Hu, Haoran Zhao, Guowei Zhou in European Journal of Medical Research (2024)

  20. Article

    Open Access

    Applying the en-bloc technique in corpus callosum glioblastoma surgery contributes to maximal resection and better prognosis: a retrospective study

    Corpus callosum glioblastoma (ccGBM) is a specific type of GBM and has worse outcomes than other non-ccGBMs. We sought to identify whether en-bloc resection of ccGBMs based on T2-FLAIR imaging contributes to c...

    Tianshi Que, ** Yuan, Jian-er Tan, Haojie Zheng, Guozhong Yi, Zhiyong Li in BMC Surgery (2024)

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