219 Result(s)
-
Article
Open AccessIntegrating apaQTL and eQTL analysis identifies a potential causal variant associated with lung adenocarcinoma risk in the Chinese population
Alternative polyadenylation (APA) plays a crucial role in cancer biology. Here, we used data from the 3′aQTL-atlas, GTEx, and the China Nan**g Lung Cancer GWAS database to explore the association between apaQ...
-
Article
Open AccessCharacterization of air pollution and associated health risks in Gansu Province, China from 2015 to 2022
Air pollution poses a major threat to both the environment and public health. The air quality index (AQI), aggregate AQI, new health risk–based air quality index (NHAQI), and NHAQI-WHO were employed to quantit...
-
Article
Open AccessAdoption of the cardiopulmonary exercise test in the exercise ability and cardiopulmonary function rehabilitation of coronary artery disease (CAD) patients
This study aimed to explore the application of cardiopulmonary exercise testing in coronary artery disease (CAD) patients, evaluate its impact on exercise ability and cardiopulmonary function in patients with ...
-
Article
Open AccessConstruction and application of procedural pathways combined with information management in nursing staff skills training system
To explore the application effect of procedural pathways combined with information management in the construction of nursing staff skills training system.
-
Article
Open AccessUSP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer
This study investigates the role of USP47, a deubiquitinating enzyme, in the tumor microenvironment and its impact on antitumor immune responses. Analysis of TCGA database revealed distinct expression patterns...
-
Article
Open AccessGenomic characterization reveals distinct mutational landscapes and therapeutic implications between different molecular subtypes of triple-negative breast cancer
Triple-negative breast cancer (TNBC) has high heterogeneity, poor prognosis, and limited treatment success. Recently, an immunohistochemistry-based surrogate classification for the “Fudan University Shanghai C...
-
Article
Open AccessIntegrated analysis of the DNA methylome and RNA transcriptome during the development of skeletal muscle in Duroc pigs
Skeletal muscle development plays a crucial role in yield and quality of pork; however, this process is influenced by various factors. In this study, we employed whole-genome bisulfite sequencing (WGBS) and tr...
-
Article
Open AccessEvaluating the mosquito vector range for two orthobunyaviruses: Oya virus and Ebinur Lake virus
Mosquito-borne viruses cause various infectious diseases in humans and animals. Oya virus (OYAV) and Ebinur Lake virus (EBIV), belonging to the genus Orthobunyavirus within the family Peribunyaviridae, are recogn...
-
Article
Open AccessPerceptions of Chinese women with a history of gestational diabetes regarding health behaviors and related factors: a directed qualitative content analysis
Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy and is associated with adverse outcomes in both mothers and their children. After delivery, women who experien...
-
Article
Open AccessInter- and trans-generational impacts of real-world PM2.5 exposure on male-specific primary hypogonadism
Exposure to PM2.5, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fe...
-
Article
Open AccessCorrection: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
-
Article
Open AccessInvestigating the causal relationship between immune cell and Alzheimer’s disease: a mendelian randomization analysis
Complex interactions between the immune system and the brain may affect neural development, survival, and function, with etiological and therapeutic implications for neurodegenerative diseases. However, previo...
-
Article
Open AccessPotential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study
Myopia is the most prevalent refractive error and a growing global health concern that significantly affects visual function. Researchers have recently emphasized considerably on the influence of lifestyle on ...
-
Article
Open AccessCharacterization of intestinal fungal community diversity in people living with HIV/AIDS (PLWHA)
Acquired Immune Deficiency Syndrome (AIDS) is a highly dangerous infectious disease caused by the Human Immunodeficiency Virus (HIV), a virus that attacks the human immune system. To explore the correlation be...
-
Article
Open AccessSacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease
Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential function...
-
Article
Open AccessThe novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
The most aggressive form of breast cancer is triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER) and progesterone receptor (PR), and does not have overexpression of the h...
-
Article
Open AccessFull quantitative resource utilization of raw mustard waste through integrating a comprehensive approach for producing hydrogen and soil amendments
Pickled mustard, the largest cultivated vegetable in China, generates substantial waste annually, leading to significant environmental pollution due to challenges in timely disposal, leading to decomposition a...
-
Article
Open AccessGasdermin E dictates inflammatory responses by controlling the mode of neutrophil death
Both lytic and apoptotic cell death remove senescent and damaged cells in living organisms. However, they elicit contrasting pro- and anti-inflammatory responses, respectively. The precise cellular mechanism t...
-
Article
Open AccessHow to tackle non-specific low back pain among adult patients? A systematic review with a meta-analysis to compare four interventions
To tackle non-specific low back pain (NSLBP) among patients and find the most effective solution and to quantitatively synthesize the overall effect of motor control training (MCT) compared with Pilates, McKen...
-
Article
Open AccessGreen electrosynthesis of 3,3’-diamino-4,4’-azofurazan energetic materials coupled with energy-efficient hydrogen production over Pt-based catalysts
The broad employment of clean hydrogen through water electrolysis is restricted by large voltage requirement and energy consumption because of the sluggish anodic oxygen evolution reaction. Here we demonstrate...