![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessEarly-paleozoic rapakivi-textured granite from the North Qinling (Central China): implications for crust–mantle interactions in a post-collisional setting
Rapakivi granite is characterized by its unique structure, which has important implications for tectonic settings, magmatic processes, and crust–mantle interactions. In this study, we conducted a combined anal...
-
Article
Open AccessLongshore changes in the microfacies and distribution of clastic barrier coastal sandbodies: a case from the Benxi formation in the Ordos Basin, China
The Benxi Formation in the Ordos Basin is an important gas-producing layer in the Yanchang gas field. There are critical changes in the microfacies type and extension trend of sandbodies, which affects the und...
-
Article
Open AccessPermissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease
Renal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profib...
-
Article
Melanocortin 5 receptor signaling pathway in health and disease
Melanocortin hormone system plays a key role in maintaining the homeostasis of our body via their neuro-immune-endocrine activities and regulates a diverse array of physiological functions, including melanogen...
-
Article
Open AccessAuthor Correction: MC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake, China
There is an increasing concern that aquaculture has been implicated in the formation of antibiotic resistance gene (ARG) reservoirs; however, little is known about the consequences of their presence in groundw...
-
Article
Open AccessRNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease
Diabetic kidney disease (DKD) is one of the most common complications of diabetes, and the most common cause of end-stage renal disease, for which no effective therapies are yet available. RNA-binding proteins...
-
Article
Open AccessActivation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β pathway signaling
Ecdysone is an arthropod molting hormone and has been marketed as a non-androgenic natural anabolic and adaptogen. However, the safety profile of ecdysone is largely undetermined. After ecdysone treatment for ...
-
Article
Paleogene-Neogene stratigraphic realm and tectonic-sedimentary evolution of the Qilian Mountains and their surrounding areas
The Cenozoic uplift of Qilian Mountains is critical to comprehend the uplift and extension of the Tibet Plateau as well as the formation of the first and second steps in China’s topography. This study summariz...
-
Article
Open AccessRescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3β
Acute kidney injury (AKI) remains challenging for clinical practice and poses a risk of develo** progressive chronic kidney disease (CKD) with no definitive treatment available yet. Tanshinone IIA, an active...
-
Article
Open AccessActivation of FXR protects against renal fibrosis via suppressing Smad3 expression
Renal fibrosis is the common pathway of most chronic kidney disease progression to end-stage renal failure. The nuclear receptor FXR (farnesoid X receptor), a multiple functional transcription factor, plays an...
-
Article
Open AccessA comparison of zircon U-Pb age results of the Red Clay sequence on the central Chinese Loess Plateau
Single grain zircon U-Pb geochronology has demonstrated great potentials in extracting tectonic and atmospheric circulation signal carried by aeolian, fluvial, and fluviolacustrine sediments. A routine in this...
-
Article
Open AccessMC1R is dispensable for the proteinuria reducing and glomerular protective effect of melanocortin therapy
Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remissio...
-
Article
Open AccessMagnetic fabric from Red clay sediments in the Chinese Loess Plateau
Well-distributed eolian red clay in a wide area of northern China is believed to imply the onset of an ancient East Asian monsoon system since Late Miocene. Two continuous red clay sequences spanning the time ...
-
Article
The renaissance of corticotropin therapy in proteinuric nephropathies
Identification of effective therapies for nephrotic syndrome is challenging. The pituitary adrenocorticotropic hormone (ACTH) has been shown to be renoprotective in patients with proteinuric neuropathies, but ...
-
Article
Zircon U-Pb ages and Hf isotopic characteristics of the Dehe biotite monzonitic gneiss pluton in the North Qinling orogen and their geological significance
The Dehe granitic pluton intruded the **ahe Group which is in the core complex of the North Qinling Orogenic Belt (NQOB). It shows gneissic bedding and possesses typical S-type granite minerals such as muscovi...
-
Article
Geological characteristics, metallogenic background, and genesis of the Tongyu VHMS copper deposit in the west part of the North Qinling, Shaanxi Province
The Tongyu volcanic-hosted massive sulfide (VHMS) copper deposit is located in the west part of the North Qinling (NQL), Shaanxi Province. Here we report geological features and trace elemental characteristics...
-
Article
Zircon U-Pb dating and geochemical study of the **anggou granite in the Ma’anqiao gold deposit and its relationship with gold mineralization
Single zircon LA-ICP-MS U-Pb dating and lithogeochemical studies have been performed on the **anggou monzonitic granitic porphyry outcropped in the Ma’anqiao gold deposit. A weighted average U-Pb age of 242.0±...
-
Article
Middle Pleistocene mammalian fauna of Shanyangzhai cave in Qinhuangdao area, China and its zoogeographical significance
The mammalian fauna with clear characteristics of transitional region has been found in the Shanyangzhai cave of the Qinhuangdao area where the three Chinese zoogeographical regions (the Northeast region, the ...