13 Result(s)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Novel therapeutic evaluation biomarkers of lipid metabolism targets in uncomplicated pulmonary tuberculosis patients

Currently, the management of pulmonary tuberculosis (TB) lacks potent medications and accurate efficacy evaluation biomarkers. In view of the fact that the host lipids are the important energy source of Mycobacte...

Jia-** Chen, Yu-Shuai Han, Shan-Qiang Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer treatment. However, there are many patients who failed to benefit from these therapies, highlighting ...

Miaoqin Chen, Shiman Hu, Yiling Li… in Signal Transduction and Targeted Therapy (2020)

Article

Randomized, multicenter, open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer: NCT01631357

Liang Liu, Quanli Gao, **gting Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients

This study aimed to investigate the prognostic value of the potential biomarker collagen triple helix repeat containing 1 (CTHRC1) in lung adenocarcinoma (LUAD) patients.

Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang… in Cancer Cell International (2019)

Article

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer

Tyrosine kinase inhibitors for epidermal growth factor receptor (EGFR TKIs) greatly improved clinical outcomes of patients with non-small cell lung cancer (NSCLC). Unfortunately, primary and acquired resistanc...

Lixian Yang, Shilong Ying, Shiman Hu… in Signal Transduction and Targeted Therapy (2019)

Article

Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and...

Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou… in Cancer Cell International (2019)

Article

Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients

It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an importan...

Lujun Chen, Dawei Zhu, Jun Feng, You Zhou, Qi Wang… in Cancer Cell International (2019)

Article

MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway

The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-...

**ghui Hu, Wei Zhao, Yujie Huang, Zhe Wang, Tingting Jiang… in Cancer Cell International (2019)

Article

Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer

Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that ...

Lujun Chen, Jun Feng, Shaoxian Wu, Bin Xu, You Zhou… in Cancer Cell International (2018)

Article

Correction to: Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance

Following publication of the original article [1], the authors reported a ty** mistake in the title. In this Correction the incorrect and correct titles are shown.

Lujun Chen, Jun Feng, Bin Xu, You Zhou, … in Cancer Cell International (2018)

Article

Expression of B7-H6 expression in human hepatocellular carcinoma and its clinical significance

Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its ...

Lujun Chen, Jun Feng, Bin Xu, You Zhou, … in Cancer Cell International (2018)