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Article
**su Park
Biomedicine, general
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Article
Open AccessConsistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY
Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at higher risk of infection and adverse outcomes. The re...
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Computational analysis on 3D airway model of obstructive sleep apnea patient for optimal maxillomandibular advancement
Obstructive sleep apnea (OSA) can have many adverse effects on people’s health, including cognitive decline and high blood pressure. Typical surgical treatment methods include the commonly performed uvulopalat...
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Open AccessThe role of cytoreductive nephrectomy in metastatic renal cell carcinoma in immune-oncology era (SEVURO-CN): study protocol for a multi-center, prospective, randomized trial
The role of cytoreductive nephrectomy (CN) in the treatment of metastatic renal cell carcinoma (mRCC) remains unclear in the immuno-oncology (IO) era. The results of two randomized trials, CARMENA and SURTIME,...
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Open AccessProspective validation of a mobile health application for blood pressure management in patients with hypertensive disorders of pregnancy: study protocol for a randomized controlled trial
Hypertensive disorders of pregnancy (HDP) pose significant risks to both maternal and fetal health, contributing to global morbidity and mortality. Management of HDP is complex, particularly because of concern...
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Open AccessDevelopment of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining testicular characteristics and spermatogenesis. Conventional 2D and t...
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Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, t...
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Persistence and enrichment of dominant T cell clonotypes in expanded tumor-infiltrating lymphocytes of breast cancer
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown promising results in cancer treatment, including breast cancer. However, clonal dynamics and clinical significance of TIL expansion e...
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3D Bioprinting Strategies for Articular Cartilage Tissue Engineering
Articular cartilage is the avascular and aneural tissue which is the primary connective tissue covering the surface of articulating bone. Traumatic damage or degenerative diseases can cause articular cartilage...
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The effects of medial soft tissue release for varus deformity during medial open wedge supramalleolar osteotomy: a cadaveric study
This study was performed to investigate the effects of fibular osteotomy and release of medial soft tissues including posterior tibial tendon (PTT), and deep deltoid ligaments, which act as medial stabilizing ...
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Open AccessMAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Develo** mouse incisors allows inspection of the role of the stem cell niche ...
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Investigation of operation and degradation mechanisms in ZnTeSe blue quantum-dot light-emitting diodes by identifying recombination zone
ZnTeSe quantum dots (QDs), recognized as promising eco-friendly blue electroluminescent emitters, remain under-explored in light-emitting diode (LED) applications. Here, to elucidate the operation and degradat...
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Open AccessFGFR3 drives Aβ-induced tau uptake
The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD). However, the underlying mechanisms through which Aβ contributes to...
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Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review
Drug delivery to the brain is difficult, owing of the presence of a unique structure called the blood–brain barrier (BBB). Thus, strategies that facilitate drug delivery to the brain lesion sites via BBB penet...
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Computational analysis of electrode structure and configuration for efficient and localized neural stimulation
Neuromodulation technique using electric stimulation is widely applied in neural prosthesis, therapy, and neuroscience research. Various stimulation techniques have been developed to enhance stimulation effici...
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Open AccessPHGDH: a novel therapeutic target in cancer
Serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal p...
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Intranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain
This study aimed to reduce cancer-associated pain by blocking pain signals through the intranasal administration of siRNA targeting the NMDA subunit NR2B (siNR2B).
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HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model
The hallmarks of spondyloarthritis (SpA) are type 3 immunity-driven inflammation and new bone formation (NBF). Macrophage migration inhibitory factor (MIF) was found to be a key driver of the pathogenesis of S...
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New insights into the ontogeny, diversity, maturation and survival of long-lived plasma cells
Plasma cells are unique immune effectors, capable of producing large amounts of high-affinity antibodies that protect against pathogenic infections. Although most plasma cells have short lifespans, certain con...
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Cancer fatalism, social media informational awareness, and education
Understand if cancer fatalism among adult social media users in the United States is linked to social media informational awareness and if the relationship varies by education level.
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Open AccessCorrection: Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials
