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Article
Open AccessGreen fluorescent protein as a reporter of prion protein folding
The amino terminal half of the cellular prion protein PrPc is implicated in both the binding of copper ions and the conformational changes that lead to disease but has no defined structure. However, as some struc...
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Article
The genome of the cucumber, Cucumis sativus L.
Jun Wang and colleagues report the genome sequence of the cucumber. The cucumber genome is the seventh plant genome sequence to be reported and was assembled with a combination of traditional Sanger and next-g...
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Article
Kindlin-2 inhibited the growth and migration of colorectal cancer cells
Activation of Wingless (Wnt)/beta-catenin signaling is a hallmark of colorectal carcinoma (CRC). It is very important to find out the molecular mechanism for the hyperactivation of Wnt/beta-catenin signaling a...
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Article
Open AccessRole of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial
The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C...
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Article
Open AccessDifferential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database
In terms of biological behavior, gene regulation, or signaling pathways, there is a certain similarity between tumorigenesis and embryonic development of humans. Three germ layer structure exhibits the distinc...
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Article
Open AccessGenetic expression and mutational profile analysis in different pathologic stages of hepatocellular carcinoma patients
The clinical pathologic stages (stage I, II, III-IV) of hepatocellular carcinoma (HCC) are closely linked to the clinical prognosis of patients. This study aims at investigating the gene expression and mutatio...
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Article
Electroacupuncture enhances resting-state functional connectivity between dorsal caudate and precuneus and decreases associated leptin levels in overweight/obese subjects
Electroacupuncture (EA) is a safe and effective method for treating obesity. However, how it modulates reward-related brain activity/functional connectivity and gut hormones remains unclear. We employed restin...