87 Result(s)
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Article
**ng-shen Chen
Science, Humanities and Social Sciences, multidisciplinary
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Open AccessLow-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes
Long-read sequencing, exemplified by PacBio, revolutionizes genomics, overcoming challenges like repetitive sequences. However, the high DNA requirement ( > 1 µg) is prohibitive for small organisms. We develop...
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Open AccessA widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program
Transcription is crucial for the expression of genetic information and its efficient and accurate termination is required for all living organisms. Rho-dependent termination could rapidly terminate unwanted pr...
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Open AccessDirect visualization of stacking-selective self-intercalation in epitaxial Nb1+xSe2 films
Two-dimensional (2D) van der Waals (vdW) materials offer rich tuning opportunities generated by different stacking configurations or by introducing intercalants into the vdW gaps. Current knowledge of the inte...
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Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Open AccessDesign of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations
We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence genera...
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Open AccessShape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating
Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by ...
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Observation and quantification of the pseudogap in unitary Fermi gases
The microscopic origin of high-temperature superconductivity in cuprates remains unknown. It is widely believed that substantial progress could be achieved by better understanding of the pseudogap phase, a nor...
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Open AccessElectrically and mechanically driven rotation of polar spirals in a relaxor ferroelectric polymer
Topology created by quasi-continuous spatial variations of a local polarization direction represents an exotic state of matter, but field-driven manipulation has been hitherto limited to creation and destructi...
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Open AccessMutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response
Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The ...
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Open AccessRegulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry
Since November 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the worldwide pandemic of the coronavirus disease 2019 (COVID-19), the impact of which is huge to the lives of ...
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Open AccessAntibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the...
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Open AccessReentrance of interface superconductivity in a high-Tc cuprate heterostructure
Increasing the carrier density in a Mott insulator by chemical do** gives rise to a generic superconducting dome in high temperature superconductors. An intriguing question is whether a second superconductin...
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Open AccessInsights into the missing apiosylation step in flavonoid apiosides biosynthesis of Leguminosae plants
Apiose is a natural pentose containing an unusual branched-chain structure. Apiosides are bioactive natural products widely present in the plant kingdom. However, little is known on the key apiosylation reacti...
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Open AccessReactive wetting enabled anchoring of non-wettable iron oxide in liquid metal for miniature soft robot
Magnetic liquid metal (LM) soft robots attract considerable attentions because of distinctive immiscibility, deformability and maneuverability. However, conventional LM composites relying on alloying between L...
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Open AccessCD44 connects autophagy decline and ageing in the vascular endothelium
The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in vascular endothelial cells (VECs) remain unclear. Here...
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Open AccessTuring structuring with multiple nanotwins to engineer efficient and stable catalysts for hydrogen evolution reaction
Low-dimensional nanocrystals with controllable defects or strain modifications are newly emerging active electrocatalysts for hydrogen-energy conversion and utilization; however, a crucial challenge remains in...
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Open AccessPhosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intr...
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Precessing jet nozzle connecting to a spinning black hole in M87
The nearby radio galaxy M87 offers a unique opportunity to explore the connections between the central supermassive black hole and relativistic jets. Previous studies of the inner region of M87 revealed a wide...
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Open AccessUnreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos
Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is considered to be an epig...
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Open AccessLarge depth-of-field ultra-compact microscope by progressive optimization and deep learning
The optical microscope is customarily an instrument of substantial size and expense but limited performance. Here we report an integrated microscope that achieves optical performance beyond a commercial micros...
