23 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
**ng-li Gan
Article
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Article
Reovirus, isolated from SARS patients
Bei**g has been severely affected by SARS, and SARS-associated coronavirus has been confirmed as its cause. However, clinical and experimental evidence implicates the possibility of co-infection. In this repo...
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Open AccessExtended Loop Region of Hcp1 is Critical for the Assembly and Function of Type VI Secretion System in Burkholderia pseudomallei
The Type VI Secretion System cluster 1 (T6SS1) is essential for the pathogenesis of Burkholderia pseudomallei, the causative agent of melioidosis, a disease endemic in the tropics. Inside host cells, B. pseudomal...
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Open AccessA second generation SNP and SSR integrated linkage map and QTL map** for the Chinese mitten crab Eriocheir sinensis
The Chinese mitten crab Eriocheir sinensis is the most economically important cultivated crab species in China, and its genome has a high number of chromosomes (2n = 146). To obtain sufficient markers for constru...
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Open AccessIsolation and characterization of a spotted leaf 32 mutant with early leaf senescence and enhanced defense response in rice
Leaf senescence is a complex biological process and defense responses play vital role for rice development, their molecular mechanisms, however, remain elusive in rice. We herein reported a rice mutant spotted le...
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Open AccessDeterministic Spin-Orbit Torque Induced Magnetization Reversal In Pt/[Co/Ni] n /Co/Ta Multilayer Hall Bars
Spin-orbit torque (SOT) induced by electric current has attracted extensive attention as an efficient method of controlling the magnetization in nanomagnetic structures. SOT-induced magnetization reversal is u...
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Open AccessScreening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis
Pulmonary tuberculosis (TB) is among the diseases with the highest morbidity and mortality worldwide. Effective diagnostic methods for TB are lacking. In this study, we investigated long non-coding RNAs (lncRN...
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Open AccessDirected self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there c...
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Open AccessThermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection
New strategies with high antimicrobial efficacy against multidrug-resistant bacteria are urgently desired. Herein, we describe a smart triple-functional nanostructure, namely TRIDENT (Thermo-Responsive-Inspire...
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Open AccessAcetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early pathological event in neuro...
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Open AccessAn amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination
Immunological adjuvants are essential for successful cancer vaccination. However, traditional adjuvants have some limitations, such as lack of controllability and induction of systemic toxicity, which restrict...
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Open AccessA targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer, primarily hepatocellular carcin...
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Open AccessCrystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P
Besides the canonical RNA-based RNase P, pre-tRNA 5’-end processing can also be catalyzed by protein-only RNase P (PRORP). To date, various PRORPs have been discovered, but the basis underlying substrate bindi...
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Open AccessA retrospective study on the clinicopathological and molecular features of 22 cases of natural killer/T-cell lymphoma in children and adolescents
Natural killer/T-cell lymphoma (NKTCL) in children and adolescents is a rare type of T/NK cell neoplasms. The aim of the present study was to analyze the clinicopathological and genetic features of this rare e...
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Open AccessReversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts
Insufficient tumor accumulation and distribution of photosensitizers as well as low antitumor immunity severely restrict the therapeutic efficacy of photothermal therapy (PTT). Cancer-associated fibroblasts (C...
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Open AccessCholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex
The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’...
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Open AccessBond engineering of molecular ferroelectrics renders soft and high-performance piezoelectric energy harvesting materials
Piezoelectric materials convert mechanical stress to electrical energy and thus are widely used in energy harvesting and wearable devices. However, in the piezoelectric family, there are two pairs of propertie...
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Open AccessGreenhouse warming and internal variability increase extreme and central Pacific El Niño frequency since 1980
El Niño has been recorded to change its properties since the 1980s, characterized by more common extreme El Niño and Central Pacific (CP) El Niño events. However, it is still unclear whether such change is ext...
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Open AccessSpatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogene...
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Open AccessConfining donor conformation distributions for efficient thermally activated delayed fluorescence with fast spin-flip**
Fast spin-flip** is the key to exploit the triplet excitons in thermally activated delayed fluorescence based organic light-emitting diodes toward high efficiency, low efficiency roll-off and long operating ...
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Open AccessImpaired histone inheritance promotes tumor progression
Faithful inheritance of parental histones is essential to maintain epigenetic information and cellular identity during cell division. Parental histones are evenly deposited onto the replicating DNA of sister c...
